David Nickles https://www.psymposia.com/author/david-nickles/ Mon, 15 May 2023 22:12:25 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 /wp-content/uploads/2021/12/cropped-png-favicon-new-red-70x70.jpg David Nickles https://www.psymposia.com/author/david-nickles/ 32 32 Church of Psilomethoxin, Part 4: The Church That Cried Capitalism https://www.psymposia.com/magazine/church-of-psilomethoxin-part-4-the-church-that-cried-capitalism/ Mon, 15 May 2023 22:12:25 +0000 https://www.psymposia.com/?p=85897 The Church of Psilomethoxin claims it’s the victim of “psychedelic capitalism,” but almost everything it claims is wrong.

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Russell Hausfeld contributed to the reporting of this story.

This is Part 4 of Psymposia’s investigation into the Church of Psilomethoxin. Click the links for Part 3Part 2, and Part 1.

In July of 2022, The Intercept reported on politicians like avowed anti-anti-fascist Dan Crenshaw and MAGA figurehead Matt Gaetz — as well as Democratic Socialist Alexandrea Ocasio-Cortez — rallying around legislation aimed at researching psychedelics for PTSD in veterans. While bipartisan efforts to “support the troops” are nothing new, the fact that politicians were advocating to dose veterans with psychedelics generated a relative flurry of media attention. 

The strategy of focusing on veterans, at least in the context of psychedelic medicalization, originated with the Multidisciplinary Association for Psychedelic Studies (MAPS). However, having demonstrated a degree of “success” with this strategy, MAPS is no longer alone in taking this approach. Whether it’s corporations like Wesana Health and Unlimited Sciences using Marine Corps scout snipers to promote psychedelics for understudied interventions (such as treating traumatic brain injuries) or former Seal Team 6 members creating advocacy organizations like Veterans Exploring Treatment Solutions (VETS), it’s become increasingly commonplace to find groups emphasizing their work with veteran populations in order to open Republican wallets and get Uncle Sam off their backs.

In 2019, MAPS founder Rick Doblin said the quiet part out loud to Boston magazine:

“There has been this conservative crossover. We got a pledge recently of $2.7 million from Elizabeth Koch, who is Charles Koch’s daughter, and we have gotten donations from Rebekah Mercer. We have managed to have incredibly good coverage on Fox News. We have had coverage on Breitbart, the Daily Caller, military websites, Navy Seal websites. I think the choice of working with PTSD and MDMA with a lot of veterans has been fundamental to our success. It’s insulated us from this ‘psychedelics, left-wing, counterculture hippies’ thing that we have taken 50 years as a culture to get past.”

In a recent interview with Martin Ball (a longtime 5-MeO-DMT practitioner who has admitted to vomiting on clients and engaging in other harmful practices), Church of Psilomethoxin (CoP) co-founder Ian Benouis, who is also a veteran, revealed that “supporting the troops” is a core component of his legal strategy for establishing entheogenic churches. Benouis’ statements on Ball’s podcast indicate that some of his legal advice for entheogenic churches involves operating in areas with conservative laws restricting government interference with religious practices (places like Florida and Texas), and maintaining public relation strategies which he believes make the government less likely to target the churches. 

Benouis said on the podcast, “We ask all our clients, ‘Are you working with veterans?’ And if they say ‘No,’ we ask ‘Why not?’” 

He explained that, in his opinion, the government doesn’t want to deal with the optics of busting a church that has helped out veterans. Demonstrating this strategy, CoP launched its church on Veteran’s Day 2021 and claimed in its Welcome Booklet that “veterans played a major role in assisting [Church] efforts” in bioassaying its sacrament. In other words, the Church claims to have used veterans as human guinea pigs to test its unverified, purportedly-novel drug.

It’s currently unknown whether or not Benouis’ “shield of veterans” strategy might deter zealous federal prosecutors from taking a closer look at CoP. However, the recent controversy surrounding the Church and its psilomethoxin-free mushrooms has led the Church to claim it is being victimized — not as a result of religious persecution by the state, but by “psychedelic capitalists.”

In its April 13 response to the Williamson and Sherwood preprint (a recent manuscript detailing chemical analysis which failed to detect any psilomethoxin in a sample of the Church’s sacrament), the Church claims that the preprint presents: 

“…a textbook example of the evils and horrors of psychedelic capitalism. These are the same evils and horrors many have speculated about, but had not previously seen, at least to this degree.”

What, exactly, are these “evils and horrors?” We don’t know, as the Church fails to provide any specifics in its response (beyond misidentifying Usona as a for-profit institution and presenting the specter of social media posts about an unrelated company, Panacea Plant Sciences, filing psilomethoxin patents). 

There truly are horrors of capitalism — and Psymposia has covered a number of the intersections of capitalism and psychedelics. Things like ATAI Life Sciences founder and COMPASS Pathways megafunder, Christian Angermayer’s, inclusion on the Presidential Advisory Committee for the murderous Rwandan dictator, Paul Kagame; the relationship and sheer volume of connections between psychedelic corporations and extractive industry; and the industry-wide silence in the face of therapist abuse caught on camera, to name just a few.

With regards to how they are victims of “psychedelic capitalism,” the Church vaguely gestures at “capitalist gatekeepers” with “monetary interests” who desire to “oust” the Church in service to “protecting their IP interests and exclusive control over new psychedelic compounds or any and all aspects of psychedelic therapy,” but fails to provide specifics.

There appear to be at least two glaring problems for CoP within this argument. 

First, neither the Church nor anyone else has identified “new psychedelic compounds” for gatekeeping in any of the Church’s mushrooms — a point which the Church (now) freely admits. 

Second, setting aside questions about the lack of safety and efficacy of psychedelic-assisted therapy, the Church is a religious organization, not a provider of medical services. When Psymposia asked Church co-founder Greg Lake if CoP considers what it does to be psychedelic therapy, Lake replied,  “No I don’t… I don’t at all consider it, you know, psychedelic therapy.” As such, even if a company were able to exercise exclusive control over psychedelic therapy, it seems unlikely that would impede Church practices.

If someone were interested in offering a coherent critique of the Usona Institute and the capitalist interests that intersect with the organization, they might choose to focus on things like the shareholder oppression lawsuit that was filed against President and Co-Founder of Usona, Bill Linton, and his biotech firm, Promega Corporation. Among other things, the lawsuit alleged that Linton was inappropriately discounting the share price of Promega in order to operate Promega “for himself personally, Usona, and what he calls ‘humanity at large.’” Linton and Promega settled the suit for over $300 million, after the trial judge floated the idea of dissolving Promega in order to pay back shareholders if the parties couldn’t reach an independent settlement.

Additional questions about Usona might focus on longtime extractive energy executive Carey Turnbull’s involvement in the organization. In addition to his time as President and Treasurer of the non-profit Heffter Research Institute, Turnbull has fought against patents filed by COMPASS Pathways via his organization Freedom To Operate. However, as information has come to light about Turnbull’s role as founder and CEO of the for-profit Ceruvia Life Sciences — and Ceruvia’s attempts to develop and patent a synthetic psilocybin product, SYNP-101, to treat obsessive-compulsive disorders, cluster headaches, and alcohol use disorders — people have questioned the degree to which Turnbull’s opposition to COMPASS’ psilocybin patents stemmed from his own financial interests rather than out of service to public interest. Attorney Matt Zorn has described some of Turnbull’s commercial efforts as “Hot Psilocybin Patent Garbage.”

Taken further, someone might wonder if Usona’s arrangements with various research teams could present bottlenecks or strangleholds on developments related to psilocybin-assisted therapies, particularly with regards to data or intellectual property. One could even speculate or raise questions about what actually took place behind the scenes at the “gold shovel” Usona groundbreaking, where Promega executives, Usona personnel, bank presidents, and politicians like Rick Perry found themselves literally shoulder-to-shoulder. There’s certainly no shortage of questions that could be asked about what happens at the intersection of right-wing politicians, financial executives, and understudied medical interventions involving boundary-dissolving, suggestibility-enhancing drugs.

However, none of these lines of inquiry present meaningful capitalist motivations for two chemists, employed by Usona, to analyze the Church’s sacrament. It seems far more likely that the chemists — whose work has included synthesizing and studying novel psilocybin analogs — became interested in the claims the Church was making about the novel biosynthesis of an otherwise labor-intensive and fragile molecule. Alex Sherwood, listed as the corresponding author on the preprint manuscript, declined to comment for this article, telling Psymposia he’d prefer to let the science speak for itself during the preprint’s public peer-review period, and indicating there will be forthcoming updates prior to submitting the manuscript for formal peer-review.

It appears that on April 22, CoP Co-Founder Ian Benouis became aware of the lawsuit against Linton and Promega, taking to his Facebook to share a 2016 news article about the lawsuit and writing, “Usona is no longer a non-profit corporation, they are a public benefit corporation like MAPS.  I wonder if they will seek investor money also?  How does that benefit the public?” In a Facebook post the prior day, Benouis wrote (inaccurately), “Promega is a for profit company that is a wholly owned subsidiary of Usona, a non-profit medical research organization.” 

In a subsequent post, Benouis again inaccurately wrote, “[updated for accuracy] Promega is a for profit company that is a wholly owned subsidiary of Usona, a Public Benefit Corporation like MAPS” (square brackets in the original).

It is unclear why Benouis now believes that Usona is no longer a non-profit, as the Usona website FAQ states, “Usona is structured as a 501(c)(3) non-profit medical research organization. An MRO is a specific type of 501(c)(3) non-profit organization, designed to be engaged in the continuous active conduct of medical research.” 

It is similarly unclear why Benouis believes Promega is a “wholly owned” subsidiary of Usona in light of the fact that — following the 2020 settlement of the shareholder oppression lawsuit — Eppendorf AG, a German life sciences company, acquired a 13.7% stake in Promega. A stake which was explicitly acknowledged in Eppendorf’s 2020 and 2021 annual reports.

Psymposia contacted Usona to inquire whether its personnel or any partners of Usona are attempting to commercialize psilomethoxin; the synthesis methods the church claims to use to produce psilomethoxin; or any intellectual property and/or synthesis methods related to the production of psilomethoxin or related compounds. Psymposia also inquired about Usona’s non-profit status and relationship to Promega. 

In response to Psymposia’s inquiries, Usona spokesperson Karen Burkhartzmeyer wrote “Promega Corporation is a ‘C-Corporation’ domiciled in Wisconsin. A life science company founded in 1978, Promega is private and independent.” With regards to Usona’s non-profit status, Burkhartzmeyer wrote, “Usona Institute is a 501(c)(3) medical research organization, legally independent of Promega with its own board of directors….founded in 2014.” And finally, replying to the questions about psilomethoxin, Burkhartzmeyer concluded, “Neither organization has any interest in pursuing development or commercial activities regarding psilomethoxin.”

The Usona Institute’s email response to Psymposia’s inquiries

This, in turn, brings us to the question of how an organization making such dubious and demonstrably incorrect claims was able to gain so much traction within psychedelic spaces. The next article in this series will explore how psychedelic media organizations facilitate the promotion of questionable claims and misinformation by groups like the Church of Psilomethoxin and ultimately contribute to a space populated by charlatans and bad actors.

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Church of Psilomethoxin, Part 3: Matters of Faith. Father, Son, and Wholly Dosed? https://www.psymposia.com/magazine/church-of-psilomethoxin-part-3-matters-of-faith-father-son-and-wholly-dosed/ Wed, 10 May 2023 01:17:48 +0000 https://www.psymposia.com/?p=85892 The Church of Psilomethoxin now admits that its claims about psilomethoxin are solely based on faith. But how strong are the religious convictions of the Church?

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Russell Hausfeld contributed to the reporting of this story.

This is Part 3 of Psymposia’s investigation into the Church of Psilomethoxin. Click the links for Part 2 and Part 1.

Following more than a year of claims about the presence of psilomethoxin in the Church of Psilomethoxin’s (CoP) sacramental mushrooms — and recent revelations that these claims appear to be false  — the Church has offered a new take on its sacrament. It now states, “Our claims to the existence of Psilomethoxin, at this time, are solely based on faith, bolstered by our and our members’ own direct experiences with the Sacrament.”

One immediate question raised by this assertion is what, exactly, the “Anesthesiologist MD” Church member (discussed in Part 1 and promoted on CoP’s website) who injected Church sacrament “into numerous persons” understood themselves to be doing, and how likely it is to qualify as malpractice (whether faith-based or otherwise). Psychedelic chemist David Nichols told Psymposia, “Most Iikely the material injected into humans is a crude mushroom extract containing psilocybin and psilocin. Subjective experiences or faith by the church members is not acceptable as an analysis method.”

But this isn’t the only issue of “faith” (or safety) with regards to CoP. The Church’s response to the Williamson and Sherwood preprint states that “As a group of religious practitioners, the Church is entitled to rely on faith in believing that its sacrament contains Psilomethoxin. Other established religious organizations make claims their sacrament contains or represents certain things which it can not prove scientifically.”

Notably, CoP fails to specify the other religious organizations to which it is referring, or which sacraments it is likening to the mushrooms it cultivates and ships to its members. Perhaps the biggest question is how many of those sacraments contain Schedule 1 substances, unbeknownst to the people receiving them.

In addition to the health, safety, and ethical issues of giving people substances without their knowledge and informed consent, it is a federal crime for Church members to purchase (and the Church to sell) psilocybin- and psilocin-containing mushrooms, as well as to receive these scheduled drugs through the mail. 

In other words, CoP appears to be exposing its members to legal risk without their knowledge or ability to consent to that risk. The Church has repeatedly asserted that its sacrament is psilomethoxin — not psilocybin or psilocin. Therefore, CoP members arrested for receiving psilocybin-containing mushrooms could have a harder time claiming religious protections, as their sacramental mushrooms would be devoid of sacrament.

In its response to Williamson and Sherwood (the chemists who wrote the preprint debunking CoP’s sacramant, and who work for the Usona Institute), the Church states, “USONA chose to zero in on our Church for no apparent reason. The fact remains that faith is a perfectly normal, accepted, and fundamental part of most, if not all, religions.”

Alternatively, it could be that the reason that Williamson and Sherwood “zeroed in” on the Church was because it was making extraordinary claims about a novel psychedelic compound — one that has been a subject of interest for drug nerds ranging from anonymous forum lurkers to respected chemists like Alexander Shulgin and Marc Julia for decades. 

CoP goes on to state, “It is clearly established precedent in this country that individuals are completely free and protected in their right to believe in things they cannot prove and courts in this country are strictly forbidden from entertaining such an inquiry.”

While individuals are free to believe in things they cannot prove, they should still be able to make fully-informed decisions about what they choose to put into their bodies. As it stands, Williamson and Sherwood’s results indicate that CoP has been misleading its members and selling psilocybin-containing mushrooms under false pretenses, based solely on its own leadership’s faith — and despite every analysis to-date (including those run by CoP) failing to identify any psilomethoxin in analyzed samples.

In light of the fact that multiple Church co-founders are lawyers (who have repeatedly made unfounded statements on the record), this line of reasoning raises questions as to the soundness of the legal advice they’ve been offering to their entheogenic church clientele. In his bio, Church co-founder Ian Benouis claims that together, he and fellow co-founder Greg Lake have created “over sixty entheogenic churches around the US.” It may be prudent for those religious organizations to get a second opinion.

The question remains: does Church leadership really believe that, if a Church member were to be arrested and prosecuted, a jury would find them not guilty of manufacture, possession, and distribution of Schedule I controlled substances (psilocybin and psilocin) simply because their faith led them to believe their mushrooms contained only psilomethoxin — despite all analytical evidence to the contrary? Would prosecutors accept the argument that there was no international drug smuggling from Canada or Mexico (where the Church claims to conduct the alleged psilomethoxin biosynthesis) into the US, because Church members believed that their mushrooms only contained psilomethoxin? Would any claims of belief in psilomethoxin stand up in court in light of CoP’s acknowledgement that it was unable to identify any psilomethoxin in the mushrooms it was growing and distributing?

Perhaps more importantly, does CoP believe this faith confers protection to its membership? 

In the case of entheogenic churches who adequately inform their members of the drugs they will be receiving and ingesting, prospective members have the opportunity to weigh the various risks for themselves. For example, they can consider whether or not they wish to take the risk of assuming their use of criminalized substances will be protected by a religious freedom defense. In the case of CoP, the Church has led its members to believe that there are no scheduled substances in Church sacrament. In doing so, CoP has removed an important component of informed consent.

The claims that the Church has made carry both significant physical and legal risks, and Church members have every right to be informed about these risks. But claims of faith, alongside the various misleading public statements made by the Church and its founders, raise questions as to their standing with regards to the Religious Freedom Restoration Act (RFRA). 

RFRA is a US federal law that was passed in the wake of the Supreme Court Case, Employment Division v. Smith, dealing with Native American peyote use and “ensures that interests in religious freedom are protected.” RFRA establishes that the “Government shall not substantially burden a person’s exercise of religion” unless doing so is the least restrictive means of furthering “a compelling governmental interest.”

This is relevant to CoP, as courts have historically upheld that there is a “compelling governmental interest” in mitigating the “risk” that sacramental drugs could be diverted to non-religious uses. It is unclear how the Church’s approach of selling mail-order mushrooms offers any guardrails to prevent such diversions. Furthermore, there is an open question as to whether the Church’s membership process (filling out an online questionnaire and paying a membership fee) meets the threshold of establishing membership in a bona fide religious organization.

The question of religious bona fides looms large, as at least one of the Church’s co-founders appears to suggest that the Church was created as a means of protecting the founders’ drug of choice. In a livestream interview with Zeus Tipado, co-founder Benjamin Moore said, “We knew immediately once we started working with [the allegedly psilomethoxin-containing mushrooms]…that this was something different and that we needed to protect it from any sort of interference by government or corporate America. So we needed to create some artifice of protection to protect it.”

Moore went on to tell Tipado, “So, we did just that…because that’s what America requires you to do….We churched it up because it is, it is a church. It is a holy spirit in my opinion and it lets us access the divine.”

Psymposia asked Lake what he would say to people who might suggest that the Church is really just a workaround or loophole to sell psilocybin-containing mushrooms within the context of prohibition. Lake responded “Um, well, I tell ’em, you know, look, if people feel that way…they for sure have the right to do that. You know what I mean? We’re a church. We’re a religious organization…you know, and we firmly believe that psilomethoxin is contained in our sacrament.” Lake continued, “No hard feelings here. I want people to try to make the best informed decisions for themselves. And if they don’t believe this or believe it’s a fraud or a workaround. Don’t join. That’s fine…Again, no hard feelings there.”

Moore and Lake’s words indicate that CoP might actually fit into a longstanding US tradition that has existed since the early days of drug prohibition: religious organizations constructed to provide cover from US drug laws.

One such notable organization, the Original Kleptonian Neo-American Church was founded by a disciple of Timothy Leary in the mid-’60s. In addition to claiming LSD as its sacrament, the Neo-American Church incorporated “Puff the Magic Dragon” and “Row, Row, Row Your Boat” as religious hymns. Ultimately, despite some experts identifying the Neo-American Church as having a serious, fully formed theology, the judge overseeing the 1968 court case United States vs. Kuch determined that the Church’s rituals did not merit protection under the First Amendment.

The judge’s statements that he was unable to find “a religious discipline, a ritual, or tenets to guide one’s daily existence;” that “there is a conscious effort to assert in passing the attributes of religion but obviously only for tactical purposes;” and that “it is clear that the desire to use drugs and to enjoy drugs for their own sake, regardless of religious experience, is the coagulant of this organization and the reason for its existence,” sound like he could be addressing present day CoP leadership.

CoP’s words and actions also bring to mind the Oklevueha Native American Church (ONAC) and the allegations of “pretendians” leveled against ONAC and its founder, James “Flaming Eagle” Mooney. ONAC is another religiously structured organization, predicated on providing its members with access to drugs. Perhaps the most notable branch in recent years was Ayahuasca Healings, whose leader falsely claimed to be the first legal ayahuasca church in the US. In reality, it had no legal protection whatsoever. Psymposia has previously reported on Ayahuasca Healings’ founder, as well as the involvement of ONAC members at psychedelic events and their subsequent removal from those events. In numerous online bios, Benouis claims to have “created an Oklevueha Native American Church in 2015.” 

While the Church may be building on these long-standing American traditions of questionable psychedelic religions, it also seems to be taking a decidedly 21st century approach. For example, on April 26 (nearly two weeks after the sacrament had been debunked), CoP co-founder Benjamin Moore tweeted out a video clip of a live podcast from podcaster Tim Pool, featuring a cast of right-wing characters: Alex Jones, Tim Pool, Michael Malice, and Blair White. In the clip — which Malice retweeted to his nearly 620,000 Twitter followers — Malice (appearing made up as an actual clown) and White both endorse the Church and its sacrament, with Malice explicitly stating “It is legal,” and White proclaiming “I’m a proud customer.”

And “customer” may, in fact, be a more accurate descriptor than “believer.” A post on CoP’s Instagram page proclaims, “10% commission on sacrament purchases. Invite your friends and save money,” with a caption that reads: 

“Introducing the ‘Spiritual Equity Credit’ referral program for members of the Church of Psilomethoxin. Members can earn spiritual equity credits by referring new members through their unique referral URL, which can be found in their Referral Program Dashboard in the Member Portal area. The credits can be used to subsidize payment required to obtain the Church’s sacrament offerings, making them more accessible. More info available on website, link in bio 😌

An Instagram post promoting CoP’s “Spiritual Equity Credit” program

Between CoP’s ongoing misleading statements about the presence of psilomethoxin in its mushrooms, its “referral for drug credit” scheme, and the price it charges its members for its “sacramental supplement,” it’s hard to see the Church as anything other than a pay-to-play (pay-to-pray?) international mushroom growing and selling hub. In addition to claiming to produce its mushrooms in Canada and Mexico, Benouis has publicly confirmed the Church will ship sacrament internationally.

Despite the considerable evidence that CoP has been misleading its members and the general public — and appears to be using false narratives and religious claims to sell Psilocybe cubensis mushrooms at a significant markup — the Church has been quick to assert that it is actually the victim of religious persecution at the hands of “psychedelic capitalism,” namely, the Usona Institute. Part 4 of this series will examine those claims.

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The Church of Psilomethoxin Part 2: Unraveling the Sacred Chemistry https://www.psymposia.com/magazine/the-church-of-psilomethoxin-part-2-unraveling-the-chemistry-of-canned-peas-with-david-nichols/ Wed, 03 May 2023 22:46:48 +0000 https://www.psymposia.com/?p=85866 Psymposia’s investigation into the Church of Psilomethoxin (CoP) turns to the Church’s claims that it’s currently “scientifically impossible” to test for psilomethoxin. Psychedelic chemist David Nichols calls that claim “completely nonsensical and nonscientific.

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Russell Hausfeld contributed to the reporting of this story.

This is Part 2 of Psymposia’s investigation into the Church of Psilomethoxin. Part 1 can be found here.

In a livestream with Zeus Tipado on April 25, Church of Psilomethoxin co-founder Benjamin Moore announced that the Church is reverting back to its original name, “The Church of the Sacred Synthesis.” In response, Tipado enthusiastically suggested that such a change could prevent much of the pushback CoP has recently encountered, and offered a colorful analogy. “Let’s say for example, I create the Church of Canned Peas, you know? And I’m giving people peas and canned peas and then all of a sudden somebody’s like, ‘These aren’t peas, it’s…creamed corn!’ You know, then it’s like, ‘I was under the impression that I was getting…peas, but it’s actually corn!’…If the church was called Church of Food, then it doesn’t matter what you get, corn or peas. You get whatever!”

Tipado went on to say, “Regardless…if it has psilomethoxin or if it doesn’t have psilomethoxin…I think just taking that out would just better the whole perception of the Church when people hear about it. So I’m very happy that you guys are going through that change…I think that’s going to help the entire image of the church, just that simple change.”

While changes to CoP’s website and social media pages indicate that the Church is currently exploring a “Church of Food” approach, there are still many unresolved issues and questions with regards to its claims about its sacrament: peas psilomethoxin (a name the Church trademarked in 2022).

In numerous interviews with CoP founders, as well as on its website, Church leadership references comments made in 2005 by the renowned psychedelic chemist Alexander Shulgin (whom CoP considers to be the “Church’s godfather and prophet”), regarding the possibility of a mycological biosynthesis of psilomethoxin. In the “Ask Dr. Shulgin Online” section of his website, Shulgin replies to an inquiry about why 4-HO-5-methoxy-N,N-dimethyltryptamine (psilomethoxin) wasn’t included in his book, TiHKAL, stating:

4-Hydroxy-5-methoxy-N,N-dimethyltryptamine would be a fascinating compound to explore. The reason it’s not in TiKHAL is that it is virtually unknown. The only report of it in the chemical literature was a paper published by Marc Julia’s group at the Pasteur Institute in 1965….The synthesis is quite a frightening thing….I’m not surprised that no one has pursued the compound.

However there is a very interesting study that took place in Leipzig about 15 years ago. Jochen Gartz, a mushroom explorer whom I know quite well, has done some fascinating studies with Psilocybe species by raising them on solid media containing strange tryptamines that are alien to the mushroom. Apparently the enzymes that are responsible for the 4-hydroxy group of psilocin are indifferent to what it is they choose to 4-hydroxylate….I’ll give you even odds that if you put spores of a psilocybe species on cow droppings loaded with 5-MeO-DMT you would come out with mushrooms containing 4,5-HO-MeO-DMT. This way you avoid a 10 step synthesis by growing a psychoactive mushroom that contains no illegal drug.

While Church leadership has repeatedly referenced Shulgin’s speculation as though it were established fact, it should be clear that Shulgin’s speculation is just that — speculation. Yes, it’s based on Gartz’s published work, but Gartz didn’t publish about biosynthesizing psilomethoxin.

A video from CoP's Instagram page that says the Church used the "Shulgin recipe" to produce psilomethoxin and "it seems to have worked."

CoP explanations of the biosynthesis appear a bit muddled. In some interviews CoP leaders claim the process involves adding 5-MeO-DMT freebase to the mushroom substrate, while in other interviews they claim it entails 5-MeO-DMT salts. Meanwhile, in a Facebook post, Church co-founder Ian Benouis claims “all the cows that have eaten 5-meo-dmt containing phalaris grass making manure when inoculated with psilocybin spores have naturally been making psilomethoxin for thousands of years…” The Church has not made its biosynthesis method available for public scrutiny or peer-review. 

Regarding production of the Church’s sacramental psilomethoxin, Lake told Psymposia it is made in a “production facility in Canada. People that we, you know, have a very close relationship with — or members of our church, who do it in Canada.”

Asked whether those producers confirmed the presence of psilomethoxin, Lake responded, “No, absolutely not. I mean, we all know there’s no reference sample, right? So, it’s like, you know, in our view, they couldn’t tell us one way or the other.”

When CoP was asked on its Instagram page why it hadn’t “submitted a paper for publication in a scientific journal,” the Church replied, “We are a religious organization. Not a medical or scientific one. Submitting papers to scientific journals is outside the scope of our purpose.”

The psilomethoxin assertions aren’t the only questionable claims made by CoP leadership regarding mycological biosyntheses. In a recent podcast with Martin Ball — a longtime 5-MeO-DMT practitioner who has admitted to vomiting on clients and engaging in other harmful practices — Benouis claims to “have a friend…in Oregon [who] fed THC, delta-9 THC to mushrooms and they 4-hydroxylated it.” Benouis fails to provide any supporting evidence for this claim, instead using it as a jumping off point for his belief that the “mushrooms can do the heavy lifting” of synthesizing psilomethoxin. In his conversation with Tipado, CoP co-founder Benjamin Moore repeats this 4-hydroxylated THC claim, again without evidence.

CoP’s “Scientific Response” to the Williamson and Sherwood preprint — a recent manuscript detailing chemical analysis which failed to detect any psilomethoxin in a sample of the Church’s sacrament — was written by its “Director of Sacred Science/Sacred Synthesis,” Adam McKay. McKay’s bio refers to him as a “chemist and physicist” with a BS in Chemistry and Physics, as well as a minor in Mathematics. It also claims he has worked as an analytical chemist for a dietary supplement manufacturer and two pharmaceutical companies. According to his LinkedIn, McKay’s longest period of employment was as “Manager and Head Tutor” for a company called “Integral Tutoring” for about eight years.

Psymposia contacted McKay to confirm his credentials and professional experience. McKay declined to provide verification, instead directing Psymposia to re-read his LinkedIn, disregard his tutoring “side business,” and contact Stony Brook University. Psymposia was unable to verify McKay’s claims of being a physicist.

While reporting this story and reviewing publicly available information about McKay online, Psymposia watched a video titled “Psilomethoxin Deep Dive with Chemist Adam Mckay.” In the video, Mckay attempts to unpack the biosynthesis of psilocin, explaining, “the fungi has all these enzymes that make [psilocin] by a bunch of procedures.” He then launches into a similarly vague explanation of how mushrooms (which he repeatedly refers to as “the plant”) make psilomethoxin. How likely is it that McKay will succeed in synthesizing a reference standard of psilomethoxin — a procedure Shulgin called “a frightening thing?” Only time will tell.  

In CoP’s “Scientific Response” McKay refers to Williamson and Sherwood’s paper as “Williamson and Heldreth’s paper,” seeming to confuse social media commentary from the CEO of Panacea Plant Sciences, David Heldreth, with the preprint written by the Usona researchers. McKay then claims the paper “appears to be put forth by two individuals associated with a for profit organization.” Usona Institute, the organization that employs Williamson and Sherwood, is a non-profit medical research organization. 

Rather than offering scientific analysis, McKay goes on to claim that the “chain of custody” of the sample of the alleged psilomethoxin is at issue, stating that “There is no evidence to support that it is authentic sacrament, stored and transported properly, and unadulterated.” Psymposia asked McKay what the proper storage and transportation protocols would entail, but McKay declined to comment. 

Psymposia is aware of three analyses performed on the Church’s sacrament — in addition to the multiple analyses the Church claims to have run — all of which have failed to find psilomethoxin. While CoP has raised “chain of custody” objections to the sample an anonymous Church member (whose identity Psymposia has independently verified) provided to the Usona researchers, it is unclear why it has not submitted its own sample for HPLC or UPLC analysis.

In light of McKay telling Psymposia, “I will not be commenting anything [sic] for 4 months [sic] time,” Psymposia turned to noted psychedelic chemist David Nichols for his thoughts about the Church’s statements regarding chemical analysis of its sacrament. Nichols told Psymposia that “The church has a completely nonsensical and nonscientific position.”

In response to the Church’s assertion that “No one can claim, at this juncture, positive identification of Psilomethoxin until a reference sample for comparison is obtained,” Nichols told Psymposia:

“If a reference standard was necessary to identify a new natural product, no new natural products would ever have been identified. That is simple logic that anyone can understand. You don’t need an already synthesized standard molecule before you can identify the presence of that molecule for the very first time in a natural product. Rather, the Williamson and Sherwood paper uses proper analytical methodology to show that there is nothing in their ‘psilomethoxin’ sample with the properties of the claimed compound.”

Rather than identifying specific methodological failings of the Williamson and Sherwood paper in the “Methodology” section of CoP’s response, McKay mostly opts to speak in generalizations, stating, “Chromatography is highly sensitive to solvent mixture ratios and pH yielding variable results even on the same instrument run consecutively without significant controls and safeguards in place.”  McKay continues, “In a credible analysis the method used needs to be validated and robust. With chromatography in particular, this entails such steps as repeated injections of the standard to indicate the instrument’s reliable functioning, blank measurements for background noise, and threshold of detection measurements.”

Contrasting sharply with McKay’s objections, Nichols told Psymposia that “Organic compounds can be identified by specific analytical methods such as high-resolution mass spectrometry (UPLC-HRMS), which will give the exact molecular weight of a compound out to four decimal places, allowing one to calculate the molecular formula of the compound. Ultra performance liquid chromatography was used to identify how many tryptamines were present in their standard sample. [Williamson and Sherwood] easily identified psilocybin, psilocin, and baeocystin. However, the exact molecular weight of psilomethoxin is 235.1441 and there was no additional HPLC peak corresponding to that exact molecular weight.”

A figure from the Williamson and Sherwood preprint, captioned “(Top) Selected ion chromatograms for tryptamine test mix. (Bottom) Selected ion chromatograms for Church of Psilomethoxin sample…” indicating the presence of psilocybin and psilocin, but not psilomethoxin, in a sample of CoP sacrament

It appears that CoP believes its psilomethoxin somehow remains elusive to most forms of scientific drug testing. Whether in response to GC-MS, HPLC, or UPLC testing, the Church has found reasons to cast doubt on the results, while simultaneously asserting the reliability of bioassays (eating the mushrooms and reporting the subjective experiential effects). 

In the case of Williamson and Sherwood’s analysis, McKay ultimately appeals to his own authority, contending, “As a chromatography specialist for small molecule drugs of [sic] almost a decade in FDA [Food and Drug Administration] regulated labs these findings would never stand as reported here due to the lack of the 3 aforementioned control steps alone.”

Given that the Usona chemists in question were not seeking to manufacture drugs for human consumption, citing FDA procedures seems to be a distraction from the actual question of whether or not Williamson and Sherwood’s analytical methodology was sound. Psymposia asked McKay why he chose to reference the FDA in CoP’s response, but he declined to comment.

Nichols told Psymposia that “It is reasonable to assume, based on the HPLC retention times of the standard tryptamine mixture that the authors examined, that psilomethoxin would have appeared at some point prior to the 4.5 minute total elution time of the sample. There is definitely no psilomethoxin in the sample analyzed by Williamson and Sherwood.”

Perhaps the most glaring issue with CoP’s entire “Scientific Response” is the fact that the Church and its leadership have claimed on its website that its sacramental “fruiting bodies contain only Psilomethoxin (a non-scheduled substance) and not psilocybin and psilocin.”

Church leadership has reiterated this point on numerous podcasts, or failed to correct podcast hosts who have made this point to them. So even if we were to accept all of McKay’s objections to Williamson and Sherwood’s analysis, the presence of psilocybin and psilocin in the Church mushrooms that were analyzed is adequate to debunk CoP’s claims about its sacrament. And, of course, there’s the fact that the Church has now made the argument that it never claimed to have positively identified psilomethoxin in its sacrament in the first place.

Why, exactly, is CoP leadership comfortable taking the position that they never identified psilomethoxin in their sacramental psilomethoxin? Apparently, it comes down to faith, a core component of most religions. In the United States, many religions and faith-based practices have rich histories, interwoven with attempts to avoid persecution, and the Church claims it’s no different. Who, you might ask, is persecuting CoP? According to the Church, it has become a victim of “psychedelic capitalism.” Parts 3 and 4 of this series will examine some of the Church’s claims about its faith, its persecution, and its understanding of psychedelic capitalism.

There are many arenas in which appealing to faith is perfectly acceptable. However, with regards to the intersection of faith and chemistry, Nichols told Psymposia, “Subjective experiences or faith by the church members is not acceptable as an analysis method.”

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Church of Psilomethoxin, Part 1: Sacramental Skepticism. Is the Church in Denial? https://www.psymposia.com/magazine/church-of-psilomethoxin-part-1-sacramental-skepticism-is-the-church-in-denial-church-of-the-sacred-synthesis/ Fri, 28 Apr 2023 19:47:44 +0000 https://www.psymposia.com/?p=85853 This is the first article in a series investigating the Church of Psilomethoxin (CoP), exploring the recent debate about the Church's sacrament and the people involved in promoting the Church and its claims.

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Russell Hausfeld contributed to the reporting of this story.

Editor’s note: As Psymposia was preparing to publish this article, the Church of Psilomethoxin changed its website and social media channels to refer to it as the “Church of the Sacred Synthesis.” Given that the events reported in this article occurred when the Church was calling itself the “Church of Psilomethoxin,” Psymposia has decided to continue using that name for the sake of clarity.

What happens when a group of veterans and lawyers start a psychedelic church?

It sounds like the start of a bad joke, but since Veterans Day 2021, it’s been a question that an increasing number of people have been asking about The Church of Psilomethoxin (CoP). This recently-formed “entheogenic church” — started by Ian Benouis (who participated in Psymposia’s 2015 Drug War Stories), Greg Lake, Benjamin Moore, and Ryan Begin — recognizes the drug psilomethoxin as its “universal sacrament” and “sacramental supplement,” and has been promoting its services and sacrament on a number of podcasts and social media outlets. This has left many wondering what exactly psilomethoxin is, and just how this church allegedly became the world’s largest manufacturer and distributor of this esoteric compound practically overnight. 

On its website and in various interviews, CoP claims to have developed a novel biosynthetic approach for producing its sacrament, allegedly by adding 5-MeO-DMT to the growing substrate of Psilocybe cubensis, which purportedly caused the fungus to convert the 5-MeO-DMT into psilomethoxin within the mushroom fruiting body. Throughout 2022, CoP’s homepage claimed that the “fruiting bodies contain only Psilomethoxin (a non-scheduled substance) and not psilocybin and psilocin” (emphasis added).

Once the Church approves prospective members and receives a membership fee of $55.55, the Church advertises that it ships powdered psilomethoxin-containing mushroom fruiting bodies — its spiritual sacrament — to its members for $175 for a half-ounce or $300 per ounce.

To say that these claims raised eyebrows among psychonauts would be an understatement. For years, underground chemists on web forums like the DMT-Nexus have explored “doping” mushroom substrates with a variety of chemicals, from tryptamine HCl to melatonin, and posting their findings (including analytical results) for discussion. In January of this year, a post titled “4-HO-5-MeO-DMT & The Church of Psilomethoxin” appeared on the 5 Hive forum. Two months later, in March, skeptical responses began to pop up in the thread, eventually accompanied by analytical results from high-performance liquid chromatography with ultraviolet detection (HPLC-UV) on a sample reportedly obtained from CoP. The analysis failed to detect psilomethoxin or other unexpected compounds, but did detect psilocybin, psilocin, and baeocystin.

A mass spectrometry reading of a purported sample of CoP sacrament, along with the shipping label from the Church, posted to the 5 Hive forum

On April 12 it became apparent that CoP’s claims had caught the attention of researchers operating beyond the realms of online drug forums. Usona Institute chemists Samuel Williamson and Alex Sherwood released a preprint manuscript (a preliminary version of a scientific paper made available prior to peer-review) titled, “Fungi Fiction: Analytical Investigation into the Church Of Psilomethoxin’s Alleged Novel Compound Using UPLC-HRMS,” detailing their analysis of “purported psilomethoxin material” provided by the Church, using ultra performance liquid chromatography with high-resolution mass spectrometry (UPLC-HRMS). The sample for their analysis was provided to the chemists by an anonymous CoP member, whose identity Psymposia has independently verified.

Upon analyzing the sample from the Church, the researchers concluded that their results “strongly indicate that the material distributed by the Church of Psilomethoxin does not contain the novel compound psilomethoxin (or 5-MeO-psilocybin) as claimed.” The paper closes by stating that the Church’s “claims of producing a novel compound, psilomethoxin, by incorporating 5-MeO-DMT into the substrate of cultivated Psilocybe mushrooms are more akin to ‘fungi fiction’ than reality,” asserting that, “our analysis revealed that the material distributed by the Church primarily contains known tryptamines, specifically psilocybin and psilocin, with a trace amount of baeocystin.” 

In other words, CoP appears to be sending plain old cubensis mushrooms through the mail — at a markup of $50-$200/oz compared to the street prices reported by Erowid.

The Church was quick to respond to the preprint, publishing a statement titled “Psychedelic Capitalism, Scientific Integrity, and a Wider Look Into Current Events; Response to USONA Article” on April 13. 

The statement, riddled with errors and self-contradictory claims, offers a case study in psychedelic charlatanism. For instance, throughout CoP’s response, it references Facebook comments by David Heldreth of Panacea Plant Sciences (a corporadelic firm whose website raises far more questions than it answers) and repeatedly conflates Heldreth and his comments with the preprint by the Usona chemists Williamson and Sherwood. 

When questioned about the Church confusing authorship of the preprint, Greg Lake, one of CoP’s founders, claimed the language in the Church’s response was intended to highlight Heldreth’s statements as defamatory. “A republish is just as liable as the original publisher is what I was getting at there,” Lake told Psymposia. However, the final section of CoP’s response explicitly refers to the preprint as “Williamson and Heldreth’s paper,” an error that Lake’s explanation fails to address.

In order to avoid muddying the waters further, Psymposia has chosen to focus its reporting on the points raised by the Usona researchers and CoP’s replies to those points.

Before unpacking the Church’s statement, it should be noted that on April 14, CoP’s website was set to forward all pages to entheogenesis.io. The redirect led to a $300 per ticket “one-day very intimate consciousness event” hosted by CoP and scheduled for the following day, where the “Sacrament, Psilomethoxin will be offered in ceremony for further expansion and connection to unity consciousness in their experiences throughout the day in a safe and loving container.” The Church also removed public access to its Facebook, Instagram, and YouTube pages. By April 20, it appeared CoP had begun deleting social media pages, with its Instagram profile returning an error message, rather than a private profile; but by April 23, it had returned to a publicly visible private page.

To summarize, in the days following the release of the preprint by Usona researchers, CoP leaders responded with an evasive denial and effectively took the Church website and social media channels offline. At the same time, they forwarded people to their in-person event where they planned to distribute the recently-debunked sacrament. Lake said the Church’s online presence was minimized because recent interactions were causing “very negative energy [in] our team.” 

When CoP’s website flashed back online on April 21, a message read “At this time, we are only accepting members who have been referred by another member and verified,” and most of the site’s content was only accessible to members. Most pages simply read, “This content is for Members only” and invited members to log in with their credentials. The website went offline on April 22, but on April 23 it reappeared, again with most of its content only accessible to Church members. 

Returning to the response itself, perhaps the most notable point the Church offers is its assertion that, “The individuals attacking and attempting to discredit our Church, seemingly operate off the erroneous assumption that the Church has made the claim that Psilomethoxin has been positively identified in its Sacrament. Had they taken time to read through our website content and other materials, they would have known their assumption to be incorrect.” 

Read it once. Read it twice. Then read it again. Yes, you read it correctly. The Church of Psilomethoxin says that it has never claimed to have positively identified psilomethoxin in its sacrament. However, in numerous materials reviewed by Psymposia, CoP has repeatedly asserted that its sacrament is psilomethoxin. So if the Church’s sacrament is psilomethoxin, how is it possible that its psilomethoxin doesn’t contain any psilomethoxin?

A review of CoP documents offers insight as to the claims the Church has made. For example, its Welcome Book for New Members explicitly states, “The Church of Psilomethoxin was established in November of 2021 immediately after the discovery and confirmation of our holy sacrament, Psilomethoxin” (emphasis added). While lawyers are known for splitting hairs — and this is a Church whose founders repeatedly emphasize their legal backgrounds — it seems unreasonable for the Church to argue that it never “made the claim that Psilomethoxin has been positively identified” when CoP’s own documents explicitly cite its “confirmation” of psilomethoxin.

An excerpt from the Church of Psilomethoxin: Welcome Book for New Members by Jenna Lake, Chuck Crisco, Ethereal Hope Latimer, Greg Lake, and Benjamin Moore

If we can avoid getting hung up on the contradictory notion that the Church of Psilomethoxin has never claimed to have “positively identified” psilomethoxin “in its Sacrament [psilomethoxin],” there’s a litany of claims from CoP’s website that bear examining. 

For example, on a page titled “Psilomethoxin: The History, Testing, Pharmacodynamics, and Pharmacokinetics,” the Church states:

“An Anesthesiologist MD [medical doctor] in the US who is a member of our church purified the molecule and injected it into numerous persons subcutaneously and reported no adverse responses.”

In light of CoP’s statement that it never positively identified psilomethoxin, how could it claim this anesthesiologist purified an unidentified, possibly non-existent molecule? It also raises the far more alarming question of what, exactly, this anesthesiologist “purified” and injected into “numerous persons” — especially given that they were “purifying” fungal material. 

One can’t help but think back to the case study published in 2021, which purportedly documented the case of “a 30-year-old man who injected psilocybin [‘mushroom tea’] intravenously resulting in an extended stay in the intensive care unit because of multiple-system organ failure.”

Psymposia asked Greg Lake about the claims of purification and subcutaneous injection, which CoP published on its website. Lake was quick to deny any official Church involvement, saying, “It was just merely reported to us. It wasn’t done at our direction or anything like that. So yeah, no, we didn’t like pay or command or get anybody to do that.” Lake did not elaborate as to if or how CoP attempted to verify the claims of purification and injection prior to posting them on its website, or why Church leadership chose to amplify these claims, specifically.

In a bout of apparent honesty further down the “Testing” section of the page, the Church admits:

We have performed GC-MS [gas chromatography–mass spectrometry] multiple times on our sacrament and to date, no one has been able to detect the molecule using this destructive testing process.  

According to the Church, it was unable to identify the presence of psilomethoxin via repeated analysis with gas chromatography–mass spectrometry. In other words, CoP has no evidence for the presence of psilomethoxin in its mushrooms.

However, despite a lack of any supporting evidence, CoP leadership argues this actually means that the mushrooms did contain psilomethoxin, but the analysis process destroyed the psilomethoxin in the sample. It would seem more plausible that CoP’s attempts at psilomethoxin biosynthesis failed, and that the cubensis mushrooms — which no one has demonstrated can produce psilomethoxin — failed to produce any psilomethoxin for the Church. Instead, CoP asserts:

GC-MS methods are not capable of directly analyzing drugs that are nonvolatile (does [sic] not vaporize easily), polar (water soluble), or thermally labile (destroyed by heat).

We believe that Psilomethoxin is non-volatile, polar, and thermally labile and therefore a poor candidate for testing through this process.  

Our church personally bioassays each batch of our sacrament for efficacy and safety.

Apparently, rather than analyzing their samples via other methods like readily-available HPLC (as in the case of the 5 Hive forum member) or UPLC (as in the case of the Usona researchers), the Church leaders decided that their repeated inability to identify psilomethoxin via GC-MS analysis, combined with bioassays (eating the mushrooms) actually indicated that the mushrooms “contain only psilomethoxin…and not psilocybin and psilocin.” When asked about these types of claims, Lake told Psymposia, “People have that right as an individual human to make a decision on what they want to consume themselves or not. And now, like you say with the [Williamson and Sherwood] article, there’s plenty of information out there. People can read the article, believe it, or, you know, talk to one of our members and believe them. You know?”

A CoP Instagram video, captioned, "Huge thanks to our new friend Adam McKay for this enlightening explination [sic] of the Psilomethoxin Molecule [sic]"

In numerous podcast interviews (1, 2, 3, 4, 5) CoP founders Lake, Benouis, and Moore state outright, imply, or fail to correct podcast hosts who say that CoP’s sacramental mushrooms contain “only a non-scheduled substance,” “psilomethoxin,” “mostly psilomethoxin,” “little to no psilocybin,” and other similar statements. Despite the Church’s recent denials, it seems clear that any reasonable person would understand these statements as CoP leadership claiming that the Church of Psilomethoxin grows and distributes mushrooms that contain psilomethoxin.

CoP’s April 13 reply to Williamson and Sherwood contains numerous ad hominem fallacies and generalized objections to the preprint, while offering minimal, if any, supporting evidence. At various points, the Church states: 

“…these parties seem to be so fixated on attacking and discrediting the Church that they have either seen the Church’s statements and completely disregarded them (because it doesn’t support their baseless attacks) or have not taken the time to assess the entire situation before publicly disparaging the Church.”

“…it is evident their desire to try and discredit and disparage our Church has also significantly and negatively affected the quality of their science.”

“…the article at issue is based upon extremely poor scientific standards.”

“…scientifically, the claims made in the subject article are highly dubious at best.”

“…the subject article is of such a poor scientific/methodological standard…[it] is not reflective of them meeting [US Food and Drug Administration (FDA)] standards.”

While there are numerous additional examples throughout CoP’s response, this list offers evidence of the Church’s generally dismissive statements about the Usona researchers’ findings. Furthermore, the claims about FDA standards appear to be a red herring and are particularly odd in light of the Church’s admission that it has also been unable to identify psilomethoxin in any of its samples and simply believes in its presence as a matter of “faith.” 

When questioned, Lake directed all questions regarding scientific claims to the Church’s “Director of Sacred Science/Sacred Synthesis,” Adam McKay, who declined Psymposia’s request to elaborate on why the Church referenced FDA standards or how they would be relevant to Williamson and Sherwood’s analytical findings.

Setting aside CoP’s list of vague objections, the Church’s response can largely be classified as falling into three arenas: claims about chemistry, faith, and “psychedelic capitalism,” all of which will be covered in upcoming articles. Psymposia has contacted additional psychedelic chemists and researchers to weigh in on the Church’s various claims. 

When asked about a number of chemistry-related claims, McKay told Psymposia, “I will not be commenting anything [sic] for 4 months [sic] time other than the fact that I am proceeding in the direction of validating a proposed mechanism and producing a reference standard for the church.”

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Hamilton Morris Hired by Psilocybin Startup COMPASS Pathways, Ends “Hamilton’s Pharmacopeia” On Vice https://www.psymposia.com/magazine/hamilton-morris-hired-by-psilocybin-startup-compass-pathways-ends-hamiltons-pharmacopeia-on-vice/ Wed, 22 Sep 2021 23:21:35 +0000 http://www.psymposia.com/?p=84401 Hamilton Morris, the creator of Vice’s “Hamilton’s Pharmacopeia,” will cease working with Vice on the show following the third season. He has joined psychedelic pharmaceutical corporation COMPASS Pathways as a chemistry consultant.

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Hamilton Morris — one of the world’s most renowned drug journalists — has been hired as a full-time consultant for COMPASS Pathways, a publicly traded corporation focused on medicalizing psilocybin.

According to COMPASS Pathways Chief Communications Director, Tracy Cheung, Morris will be advising the company on research related to new psychedelic compounds that could be developed into therapies. He will also carry out chemistry research at University of the Sciences in Philadelphia with the COMPASS Discovery Center team there, which is led by Dr. Jason Wallach. 

The Discovery Center was started by COMPASS in 2020 and consists of a network of labs across the United States working to develop innovative therapeutic approaches for neuropsychiatric indications, according to Wallach. 

Morris, a graduate of The New School in New York City who studied anthropology and chemistry, said: “For over a decade, Jason and I have worked together studying the chemistry and pharmacology of psychedelics. Working with the COMPASS team will allow us to make strides in developing novel psychedelics that could have tremendous medical and scientific value.”

In 2016, COMPASS Pathways quietly switched from a nonprofit entity to a for-profit entity, and has since received criticism from researchers, patent examiners, and the broader community of psychedelic users. More recently — in March 2021 — David Bronner, CEO of Dr. Bronner’s Soaps, “sounded the alarm” on “COMPASS’s interference with Oregon’s psilocybin therapy program.” Additionally, the legitimacy of COMPASS’s patents has been challenged by Freedom to Operate Inc. (FTO), a nonprofit founded by Carey Turnbull—a board member of Usona Institute, President of the Heffter Research Institute, and CEO of Ceruvia Lifesciences. Following a number of FTO challenges, a patent examiner at the UK Intellectual Property Office released an opinion stating that multiple patent claims filed by COMPASS were not inventive or novel, based on prior art

COMPASS Pathways’ CEO and founder, George Goldsmith, has a professional history of facilitating corporate networking and “cozy relationships” with regulators across industries (from resource extraction to military contractors). COMPASS recently announced its participation at Citi, Morgan Stanley, and HC Wainwright investor conferences — notable because Goldsmith previously helped rehabilitate the images of financial institutions at his previous company, Tapestry Networks, in the wake of the 2008 global financial crisis.

In 2018, Morris expressed some of his reluctance to cast judgement on the company in a discussion with Cambridge House International. Cambridge House is a company which specializes in resource investment conferences and assisting in raising capital for the junior mineral exploration industry — a risk-tolerant sector which took an early interest in psychedelic pharmaceutical investments. 

During this conversation, Morris admitted that there was a lot of controversy around “a company called COMPASS Pathways that is associated with Peter Thiel. And a lot of people in the psychedelic community are afraid that this represents the first step in a sort of corporate commodification of the psychedelic experience.” He said that he was reluctant to weigh in about the subject because he had had a lot of “difficulty finding concrete information on what COMPASS Pathways is doing.”

Morris acknowledged that there are questions of fairness that were worth addressing around corporate entities entering the psychedelic space. But he also noted that he believes corporate interest could serve the public’s benefit. 

 “I think there are a lot of people in the cannabis world who felt that they had sacrificed their freedom — people who had gone to prison, people who were activists, people who dedicated their lives to the plant — and then they felt that these newcomers, these business people, came and reaped all the benefits of their hard work,” Morris said. “But the flipside is that that sort of white-collar corporate interest, I think, had a really important role in pushing cannabis toward legalization. So there’s a push and pull there that’s important to recognize and which makes me somewhat reluctant to outright dismiss companies like COMPASS Pathways because who’s to say that that isn’t what ultimately pushes things toward the direction of legality and that would have a positive impact on everyone.”

Morris concluded his thoughts about COMPASS Pathways by saying that he was cautiously optimistic about the way things were heading and hopes “that everyone behaves responsibly and…that COMPASS Pathways doesn’t turn out to be the malevolent corporate entity that some people in the psychedelic community seem to think that they are.”

Beyond joining a controversial company, Morris’ hiring as a full-time consultant for COMPASS Pathways presents potential conflicts of interest between Morris’ journalistic career and his corporate consulting career. 

Beginning as a monthly column for Vice Magazine in 2009 and evolving into a documentary film series, Morris’ “Hamilton’s Pharmacopeia” series has become one of the most popular journalistic endeavors covering psychedelic drugs and culture. Many of his fans see Morris as one of the most trusted voices in the media when it comes to psychedelic substances. 

During an interview with “Mind and Matter” podcast, Morris indicated that — while chemistry is his current focus — he plans to continue to write, podcast, and potentially make more films in the future. In journalism, questions about conflicts of interest arise when a journalist is paid by a corporation or individual in an industry they are covering.

For example, columnist David Brooks was critiqued for using his New York Times column to promote his Facebook-funded Aspen Institute project — Weave — without disclosing his financial ties, and proceeding to write corporate blog posts for Facebook. And sports reporter Karen Crouse was recently suspended from the New York Times for writing glowing columns about Michael Phelps without disclosing that she is co-authoring a book with the swimmer. One doesn’t need to look far for other instances of this behavior among journalists.

Journalist Tim Schwab, writing for the Columbia Journalism Review, notes that “the Society of Professional Journalists — and most newsrooms — have codes of ethics that instruct journalists, in the first place to avoid conflicts of interest. Disclosure [of financial ties] is a last resort, if conflicts are absolutely unavoidable.”

Psymposia asked Morris — who, alongside being a full-time consultant for COMPASS Pathways, is also a member of the Scientific Advisory Board for the company Mind Cure Health — how he plans to navigate future conflicts of interest between his corporate consulting job and his journalistic endeavors. 

Morris has not responded to Psymposia’s requests for comment on this matter or regarding critiques of COMPASS Pathways and their patents as of publication. However, Morris did discuss his future with Vice on “Mind and Matter”, stating that he will not be working with the company on a fourth season of “Hamilton’s Pharmacopeia.” A source from Vice also informed Psymposia that they understood that Morris would no longer be working with Vice after season three of the show. 

On “Mind and Matter,” Morris said: “People will say, ‘Why are you with that dumpster fire company Vice?’ Well, it’s expensive to make documentaries…I will take money to make these projects from whoever will give it to me.” Morris said he would not be making another season of his show following season three, citing extremely long hours, lack of support from Vice, and four months of unpaid work during the pandemic. 

When asked by podcast host Nick Jikomes if he had a project that he was working on next, Morris said that he planned to work full time as a chemist for the foreseeable future.

“I think the plan is now to just do full time chemistry for a while,” Morris said. “For years I’ve worked with this brilliant chemist, Jason Wallach, at the University of the Science in Philadelphia and in recent years there has been a lot of interest in the psychedelic sphere and there’s a lot of funding that has emerged….We have funding to do some really cool work…Chemistry was, like, a thing I did on the weekends and that was great and it was a nice kind of side project in my life. But I would love to spend more time just doing chemistry. I won’t stop, you know, podcasts and writing and things like that. But unless there’s a… different network [that] offers a really miraculous sum of money to do something, I think I’m probably going to be taking a break from that and maybe I’ll try to make a movie at some point in the future.”

For now, it looks like Morris will retire his camera and film crew for beakers and burners, helping expand COMPASS’s ballooning patent portfolio.

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COMPASS Pathways Is Trying to Patent Psilocybin for More Mental Health Conditions Than You Can Name https://www.psymposia.com/magazine/compass-pathways-is-trying-to-patent-psilocybin-for-more-mental-health-conditions-than-you-can-name/ https://www.psymposia.com/magazine/compass-pathways-is-trying-to-patent-psilocybin-for-more-mental-health-conditions-than-you-can-name/#comments Thu, 18 Mar 2021 07:10:45 +0000 https://www.psymposia.com/?p=84781 News that COMPASS Pathways is attempting to patent psychedelic therapy room specifications and therapist behaviors started an online firestorm about the company’s “monopolistic and shady behaviors,” but so far the debates have missed the biggest threats lurking in COMPASS’s international patent applications.

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David Nickles

March 18, 2021

News that COMPASS Pathways is attempting to patent psychedelic therapy room specifications and therapist behaviors started an online firestorm about the company’s “monopolistic and shady behaviors,” but so far the debates have missed the biggest threats lurking in COMPASS’s international patent applications.

COMPASS Pathways' PCT application WO 2020/212952 A1

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In recent weeks, scrutiny of COMPASS Pathways’ international patent applications has caused debates over patents to break out between a collection of influential voices across the psychedelic landscape.

Tim Ferriss’s critique of psychedelic patent land-grabs—posted nearly three years after the issue was initially raised—erupted into a cross-platform open letter duel between himself and ATAI Life Sciences’ Co-Founder and COMPASS investor, Christian Angermayer—with the occasional high-profile response from Rick Doblin, the Executive Director of the Multidisciplinary Association for Psychedelic Studies (MAPS). 

Following this, MAPS Board member David Bronner—of Dr. Bronner’s Magic Soaps fame—chimed in with a blog post entitled, “Sounding the Alarm on Compass’s Interference with Oregon’s Psilocybin Therapy Program.” 

Bronner begins by expressing alarm at a recent Vice article from Shayla Love, which details COMPASS’s application to patent “a clinical setting with mood lighting, soft furniture, subdued colors and a good sound system.” Details like these—along with allegations that COMPASS has started mobilizing opposition to Measure 109 in Oregon—inspired Bronner to come out against COMPASS’s “monopolistic and shady behavior.”

@nu.hippie

How Compass Pathways envisions the future of psych3d3l1c therapy 🙄

♬ original sound – nu hippie

This high-profile back and forth between millionaire elites and psychedelic executives offered a number of questionable takes. Angermayer declared, “Capitalism…is by far the best economic system tried to date,” (on the heels of both lethal power outages in Texas due to the state’s free market fantasies and a new study on the grim realities of climate change). Ferriss preened over his role as “an early investor or advisor” in companies such as Uber and Facebook, each of which has had demonstrably corrosive effects on global society (including facilitating political violence up to and including the incitement of genocide). 

In a LinkedIn post in response to Ferriss, Angermayer stated, “Let me summarize my position as follows: The patents in question only protect very specific, synthetic, isolated compounds and associated processes, and – in my view – they represent the best means of accelerating patient access and optionality in the midst of a mental health crisis.”

Commenting on Angermayer’s post, Doblin wrote, “Your clarification is reassuring that Compass’ patent application on therapeutic methods for psilocybin is only meant to apply to the use of Compass’ specific psilocybin.” 

While Doblin’s comment—and Angerymayer’s claims—have flown under the radar and received little-to-no scrutiny, they present the most fascinating part of this online firestorm: the fact that so little of what COMPASS is actually trying to patent has been explored. While attempts to patent room specifications and therapist behaviors are certainly worth discussing, the yet-to-be-discussed components of COMPASS’s patent applications are arguably more alarming. 

COMPASS’s patents focus on “psilocybin or an active metabolite thereof,” not just COMP360 (Polymorph A)

Between COMPASS’s three (1,2,3) international Patent Cooperation Treaty (PCT) applications, the company is attempting to patent psilocybin treatment for almost every mental health condition you might think of. Not only that, the applications’ claims include treatment with “psilocybin or an active metabolite thereof.” According to Graham Pechenik, a patent lawyer with Calyx Law, “Depending on how the ultimate claims are construed, such language may arguably cover administration of any compound that is converted to the active metabolite in the body, not only administration of the active metabolite itself.”

If claims like these are approved—which is not guaranteed—they could include drugs such as 4-AcO-DMT, or CaaMTech’s recently announced novel psilocin prodrugs: 4-AcO-MET hydrofumarate, 4-AcO-MALT hydrofumarate, and 4-AcO-DALT fumarate.

Notably, these applications reach as broadly as possible and do not limit themselves to COMPASS’s already-granted COMP360 psilocybin formulation. Instead, they include a wide range of claims to “psilocybin or an active metabolite thereof,” and then also include narrower claims to their COMP360 Polymorph A—presumably as an option in the event patent examiners reject their broader “psilocybin or an active metabolite thereof” claims.

Looking at the most extensive PCT application in question—WO 2020/212952 A1—COMPASS is attempting to patent:

  • Virtually all routes of administration of psilocybin—including vaginal and rectal administration;
  • Specifications of psilocybin therapy settings including soft furniture, muted colors, high-resolution sound systems, couches or beds;
  • Specifications for patient-therapist interactions ranging from the use of breathing exercises to calm subjects; to holding a subject’s hand, arm or shoulder; to a therapist reminding a patient of at least one therapeutic intention;
  • The ability for therapists to provide psychological support remotely through a mobile phone app or website.
  • Psilocybin Treatment for subjects with Depression. This includes treatment with psilocybin or an active metabolite thereof in subjects with major depressive disorder, bipolar disorder 1 and 2, atypical depression, catatonic depression, a depressive disorder due to a medical condition, postpartum depression, premenstrual dysphoric disorder, seasonal affective disorder, treatment-resistant depression, and depression in subjects with at least one or more comorbidity such as alcoholism, anxiety disorder, Alzheimer’s disease, or cancer.
  • Psilocybin treatment for subjects with Autism Spectrum Disorder or Antisocial Personality Disorder;
  • Psilocybin treatment for subjects with ADHD;
  • Psilocybin treatment for subjects with Schizotypal (Personality) Disorder, Delusional Disorder, Schizophrenia, or Schizoaffective Disorder;
  • Psilocybin treatment for subjects with Female Sexual Interest/Arousal Disorder, Male Hypoactive Sexual Desire Disorder, or Excessive Sexual Drive;
  • Psilocybin treatment for subjects with Bipolar Disorder 1 and 2, and Cyclothymic Disorder;
  • Psilocybin treatment for subjects with Insomnia Disorder, Hypersomnolence Disorder, Narcolepsy, or Primary Central Sleep Apnea;
  • Psilocybin treatment for subjects with Schizoid Personality Disorder, Schizotypal Personality Disorder, Antisocial Personality Disorder, Borderline Personality Disorder, or Obsessive-Compulsive Personality Disorder;
  • Psilocybin treatment for subjects with Age-Related Hearing Loss or Tinnitus;
  • Psilocybin treatment for subjects who Suffer From Pain;
  • Psilocybin treatment for subjects with Multiple Sclerosis, Cranial Nerve Disorder, Neuromyelitis Optica, Bell’s Palsy, Guillain Barre Syndrome, Demyelinating Disease of Central Nervous System, or Chronic Inflammatory Demyelinating Polyneuritis;
  • Psilocybin treatment for subjects with Myelopathy, Traumatic Brain Injury, Intellectual Disabilities, Mania, Neurodegeneration, Paraphilic disorders, Suicidal Behavior Disorder, Nonsuicidal Self-Injury, Persistent Complex Bereavement Disorder, Gl Tract Related Diseases, Epilepsy, Sickle Cell Disease, locked-in syndrome, restless leg syndrome, stroke, or Amyotrophic Lateral Sclerosis (ALS);
  • Psilocybin treatment for subjects with Major Depressive Disorder;
  • Psilocybin treatment for subjects with Treatment Resistant Depression;
  • Psilocybin treatment for subjects with 61 “Diseases, Disorders, or Conditions”: In Claim 111 of application ‘952 Compass enumerates 61 different diseases, disorders, and conditions it would like to treat with psilocybin. These include—but are not even close to limited toPyromania; Selective Mutism; Cannabis-Related Disorders; Skin-Picking; and Agoraphobia
  • Psilocybin treatment for Neurocognitive Disorders due to Alzheimer’s, Lewy Bodies, Traumatic Brain Injury, Prion Disease, HIV Infection, Parkinson’s, or Huntington’s.
  • Psilocybin treatment for concussion
  • Psilocybin treatment for chronic traumatic encephalopathy (CTE);
  • Psilocybin treatment for Language Disorder, Speech Sound Disorder (Phonological Disorder);
  • Psilocybin treatment for Childhood-Onset Fluency Disorder (Stuttering);
  • Psilocybin treatment for Social (Pragmatic) Communication Disorder;
  • Psilocybin treatment for Tourette’s Disorder;
  • Psilocybin treatment for Persistent (Chronic) Motor or Vocal Tic Disorder
  • Psilocybin treatment for Amnestic Disorder Due to Known Physiological Condition;
  • Psilocybin treatment for Transient Cerebral Ischemic Attack, Cerebral Infarction, Cerebral Bleeding, Progressive Supranuclear Ophthalmoplegia, or Retrograde Amnesia.
  • This application includes all of the above claims specifically with treatment using COMPASS’s proprietary psilocybin Polymorph A, as well.

The other two PCT applications—WO 2020/212948 A1 and WO 2020/212951 A1—include a range of other conditions COMPASS is attempting to patent with psilocybin or an active metabolite thereof, including eating disorders; cluster headaches; anxiety disorders; stroke; inflammatory bowel disease; inflammation; sleep-wake disorders; and epilepsy.

The implications of these PCT applications run counter to public statements COMPASS and Angermayer have made in defense of the company’s patent strategy.

COMPASS’s website states, “The patent protection we are seeking does not cover naturally occurring mushrooms, it would not prevent others from creating different solutions for their own psilocybin synthesis, nor would it restrict others researching in this field.” In his recent response to Ferriss, Angermayer wrote that, “[COMPASS’s patents] do not infringe upon new scientific research or the rights of indigenous/sacred practice.” [Emphasis added]

Contrary to these statements, if the claims laid out in these PCT applications are granted, they would absolutely restrict others from working with psilocybin or its active metabolites for an overwhelmingly broad range of mental illnesses and conditions. 

If COMPASS’s applications for the use of psilocybin and its metabolites were to be granted as patents, it would mean that patients would need to seek permission from COMPASS for those specific treatments, or that companies would have to license the right to use psilocybin for certain treatments from COMPASS.

“These three PCT applications may become as many as ten patents or twelve patents once they hit the US in prosecution,” said Pechenik. “Companies can keep filing continuation applications with new claims, as long as there’s support in the original application. They may be willing to pay for all that because they know the outcome of getting something like psilocybin for anorexia could be millions of dollars in licensing or expanding into a market that nobody else has access to.”

Filing PCT applications fast tracks the patent application process in any of the 153 PCT contracting countries. When a PCT application is filed with the World Intellectual Property Organization (WIPO), it acts as a placeholder in these contracting countries for 30 months from the date of filing. Within that time, a company can use their PCT filing as priority documents for filing individual patents in PCT countries—saving the company from having to prepare separate applications for each different country. 

Scorched Earth

Filing broad patent applications primarily serves two strategic purposes—the first being the potential to secure approval for more claims, and the second being to interfere with competition.

“It’s now much harder for others to file their own application on treating, for example, hoarding disorder or pyromania with psilocybin, [because COMPASS has filed for that]. It scorches the earth around them and keeps others from entering the space with their own applications,” Pechenik said. 

Such strategies create an atmosphere of fear, uncertainty, and doubt for other players in the field. For example, because COMPASS has treatment of pyromania with psilocybin covered in their PCT application, this signals that they may file patents for this indication in any of the PCT countries. In turn, other companies and inventors may stay away from that practice or avoid pursuing their own patents and/or research on that indication. “It just kind of scares everybody off,” Pechenik said.

Circling back to the first strategic reason for filing broad patent claims—securing approval for more claims—one unique issue in budding industries like the psychedelic pharmaceutical space is the likelihood that many patent examiners will be looking at their very first psychedelic patents. To determine the novelty of a patent, examiners must judge its claims against the relevant prior art in its field. The chance that an average patent examiner would be familiar with prior psychedelic art is slim. 

According to Vice, patent lawyer David Casimir said that “filing broad patent applications is a common tactic—even including claims that companies know aren’t patentable. But it can lead to bad patents…If the patent office doesn’t do a good job, then they’ll say, ‘Okay, you can have this broad claim.’”

“Bad patents are bad for everyone,” Casimir told Vice. “Except maybe the patent owner who owns them. They’re just a drag on the system and an increase in cost. It slows down access to the market. It makes things more expensive.”

To avoid these situations, some organizations are attempting to make it easier for patent examiners to access information on psychedelics prior art.

Porta Sophia: A line of defense?

One effort currently underway—in which Casimir is involved as a team member—is a resource for patent examiners that work in the psychedelic space called Porta Sophia (Latin and Greek for “doorway to wisdom”). This information portal will make it easier for patent reviewers around the world to find relevant prior art, Casimir told Psymposia.

The Porta Sophia project will seek to identify all publicly available patents and applications in the space, focusing on major topics such as compositions of matter, methods of use, manufacturing, delivery systems, care protocols, and drug combinations.

Casimir notes this “is doable now, but will be more challenging in the future.”

Following their collection, highly trained reviewers will curate these applications and identify relevant prior art. This prior art will then be provided via the portal and made available through an easy-to-use interface. The project will also curate, and make searchable, information from many existing databases that will include prior art that might otherwise be challenging to find. Over time, Casimir said that Porta Sophia will seek feedback from patent reviewers to develop the system in a manner that makes their jobs easier and more efficient.

Though there is no set date for the launch of Porta Sophia, Casimir said that the team hopes to have a first version out soon.

Doblin told Psymposia that MAPS has also recently begun preparing documents to make available to the repositories that patent examiners use to review prior art.

COMPASS Investors Support Monopolies 

As shocking as COMPASS’s international patent applications may be, none of this should come as a surprise. COMPASS’s most notorious investor, Peter Thiel, has publicly stated, You shouldn’t compete, you should try to have a monopoly. Christian Angermayer recently declared that “If a monopoly/duopoly emerged…Then it would be a sign of quality and constitutional reward. In that case, you should not blame them, but blame the rest, who then clearly would have not done a good job.” Perhaps blame would actually lie with COMPASS’s business strategies and its executives who publicly state it will “absolutely not” interfere with researchers’ ability to conduct research while privately assuring investors that “many psychedelic companies out there will never be able to bring a product to market, as they will hit the patents of Compass and Atai.”

Christian Angermayer’s March 2021 email to investors shared by an anonymous source to Motherboard.

The reality is that no corporadelic monopoly or duopoly currently exists, although there appears to be an increasing likelihood of such a development. In order to understand how we wound up here—and why organizations are scrambling to construct prior art repositories like Porta Sophia as lines of defense against would-be monopolists and the forces of MarketWorld—we must acknowledge widespread complicity in allowing this to happen. Consider the overly credulous individuals and organizations who have believed COMPASS’s assertions since MAPS first started providing it with legitimacy and support dating back to at least 2016—even after it pivoted from a non-profit to a for-profit. As Nikita Alexandrov, observed in his 2020 Psychedelic Industry Insights Report, “The $300M worth of investable deals have only existed since the public formation of Compass Pathways in 2016.” 

In an effort to acquire mainstream acceptance, credibility, and fundraising dollars, many researchers and advocates of psychedelics believed that the field was immune to capitalist logic, or that incoming flows of capital were, in fact, a “sign of our success,” as Doblin likes to repeat

Similarly, in a rush to embrace feelgood narratives about the future of psychedelic mainstreaming, some media organizations have laundered COMPASS’s reputation. Rather than fact-checking or engaging in research, they’ve used their platforms to uncritically promote Doblin’s rose-colored narrative that, with regards to “the easy criticism of ‘Oh capitalism is bad, for-profit companies are bad and they are trying to do evil things with psychedelics to monopolize the market’- I don’t think that’s really happening.”

The belief that “capitalism is a good way to scale things up,” as proclaimed by Michael Pollan, has pervaded subsets of the “psychedelic community” despite all evidence to the contrary. Furthermore, Angermayer’s assertions that capitalism is “the best economic system,” and that “None of the for-profit companies will ever come knocking on somebody’s door to confiscate homegrown plants,” are red herrings intended to distract from the issue at hand: monopolistic intellectual property strategies by the world’s largest psychedelic pharmaceutical company.

We shouldn’t be surprised that COMPASS has once again demonstrated a large gap between its words and actions. This isn’t a unique situation; it’s business as usual for big pharma and psychedelic pharmaceuticals alike. Rather than assuming that psychedelic corporations will (or even can) act in the public good, proponents of mainstreaming must prove that firms can function as “exceptions” to capitalist logic (think Mondragon). But until such actors truly display a willingness and ability to swim against the tides of corporadelia, the words of COMPASS investor Peter Thiel continue to echo across the psychedelic terrain: You shouldn’t compete, you should try to have a monopoly.

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Psychedelic Media Should Stop Parroting Corporate Press Releases https://www.psymposia.com/magazine/psychedelic-science-media-corporate-press-release/ https://www.psymposia.com/magazine/psychedelic-science-media-corporate-press-release/#comments Mon, 12 Oct 2020 07:14:20 +0000 http://www.psymposia.com/?p=84572 When the media republishes statements from psychedelic pharmaceutical startups and their executives with little-to-no vetting, it functions as a corporate megaphone and damages the field of psychedelic science.

The post Psychedelic Media Should Stop Parroting Corporate Press Releases appeared first on Psymposia.

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David Nickles

David NicklesOctober 12, 2020

When the media republishes statements from psychedelic pharmaceutical startups and their executives with little-to-no vetting, it functions as a corporate megaphone and damages the field of psychedelic science.

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The push to mainstream psychedelics has included a variety of alarming decisions by psychedelic corporations, from eagerly welcoming in an advisor to “the global elite’s favorite strongman,” to claiming they want “nothing to do with those kinds of folks who want to decriminalize psychedelics,” to expressing disregard for the literal skeletons in their investors’ closets. Although less discussed, the increasing trend of corporadelic firms publishing press releases about impending scientific “breakthroughs” is also troubling.

As certain media outlets have engaged in the irresponsible practice of amplifying press release statements with little-to-no vetting, it’s worth examining how this practice can propagate false and misleading information. Media coverage of a recent press release by Mindset Pharma highlights the hazards of parroting the claims of psychedelic pharmaceutical start-ups. These corporations have incentives to make misleading statements about safe, well-known psychedelic compounds that have long histories of human use. When the media amplifies public relations narratives about the alleged superiority of understudied, proprietary drugs with unknown safety profiles, it does a disservice to psychedelic communities and those interested in learning about these compounds.

Press releases are pseudo-news stories crafted by organizations and delivered to the media for the specific purpose of advertising an organization’s products, services, or actions; they reflect the interests of the companies publishing them. Additionally, corporations have used press releases for a variety of fraudulent purposes, ranging from manipulating the value of penny stocks to making false claims about their ability to acquire N95 masks in the context of the COVID-19 pandemic.

Psychedelic media outlets often treat corporate press releases like peer-reviewed articles, which they are not. In an article titled “Peer Review in Scientific Publications: Benefits, Critiques, & A Survival Guide,” the authors offer the following explanation of “peer review”:

“Peer review has been defined as a process of subjecting an author’s scholarly work, research or ideas to the scrutiny of others who are experts in the same field. It functions to encourage authors to meet the accepted high standards of their discipline and to control the dissemination of research data to ensure that unwarranted claims, unacceptable interpretations or personal views are not published without prior expert review…Within the scientific community, peer review has become an essential component of the academic writing process. It helps ensure that papers published in scientific journals answer meaningful research questions and draw accurate conclusions based on professionally executed experimentation. Submission of low quality manuscripts has become increasingly prevalent, and peer review acts as a filter to prevent this work from reaching the scientific community. The major advantage of a peer review process is that peer-reviewed articles provide a trusted form of scientific communication. Since scientific knowledge is cumulative and builds on itself, this trust is particularly important.”

As highlighted later in this article, peer review isn’t perfect. Nevertheless, expert scrutiny helps identify methodological errors and faulty claims in publications, before they go to press, thereby helping to reduce the propagation of misinformation.

Science by Press Release: From Pandemic Promises to Oreos and Cocaine

The COVID-19 pandemic, combined with the hunt for treatments and cures, the 24-hour news cycle, and politicians desperate to resuscitate the economy has led to numerous outlets highlighting the pitfalls of science by press release. Racing to promote supposed scientific developments, particularly in the context of pandemic, can be a matter of life or death. When individuals and organizations repeat erroneous claims, they reinforce the illusion of credibility or consensus, with dire consequences. This phenomenon was put on full display when President Trump claimed that “HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine.”

On March 22, following Trump’s false claim, Christian Angermayer, co-founder of ATAI Life Sciences, tweeted, “President Trumo [sic] is absolutely right! There IS enough evidence to give Chloroquine and Azithromycin to Covid patients. These are already approved drugs, with well-understood and minor side effects.” Despite Angermayer’s emphatic assertion of the efficacy of these drugs, it turns out that his faith in both Donald Trump’s and his own grasp of medical science was severely misplaced. On August 26, Clinical Microbiology and Infection published a peer-reviewed study which concluded that “the combination of hydroxychloroquine and azithromycin increases the risk of mortality.” (emphasis added)

This recent example demonstrates some real world harms that can come from promoting claims which lack scientific validation. However, it is important to note that science by tweet or press release has a long history of causing harm and spreading misinformation. While the stakes may not always be as high as when Angermayer promoted non-treatments (and called to end social distancing as early as March 25), non-rigorous scientific reporting has disseminated misinformation far and wide. 

Such misinformation may be difficult or impossible to rectify, as demonstrated by an example in which some university students put out a press release comparing cookies to cocaine. In 2013, numerous reputable news outlets circulated a story alleging that Oreos were as addictive as cocaine. The origin of the story? A press release about an undergraduate research project at Connecticut College in New London, Connecticut. 

Experts debunked the press release almost immediately, citing methodological flaws. Outlets from Vice to The Washington Post ran stories within days, explaining why the claims made by the press release—titled, “Student-faculty research shows Oreos are just as addictive as drugs in lab rats”—were misleading, to say the least. However, today, if you Google “are Oreos as addictive as cocaine,” the front page returns a resounding, “Yes.”

Oreos are not actually as addictive as cocaine, but thanks to reporting based on a press release—at a glance—it sure appears that they are.

Is this the future that psychedelic advocates want to live in when it comes to psychedelic research?

Psychedelic Science by Press Release: A Case Study of “Non-Toxic” Alphabetamines 

In a recent Lucid News story entitled, “Mindset Pharma Reports Positive Results of Synthetic Psilocybin-Inspired Compounds,” Mindset appears to attempt to erode confidence in psilocybin, by exaggerating claims of potential danger, while suggesting its own untested novel psychoactive substances will be safer. Unfortunately, Lucid News faithfully repeats—despite very little evidence—Mindset’s claim that it is improving on the safety of psilocybin, even though centuries of human use and a litany of peer-reviewed papers demonstrate the relative safety of psilocybin. Lucid’s story offers an opportunity to examine the intersection of science by press release dynamics and the emerging corporadelic landscape. 

First, the headline is pure public relations: a company (Mindset Pharma) has reported positive results for its own product. Is that really newsworthy? Suggesting that a company has a vested interest in self-reporting positive tests of its own products should be uncontroversial and, as already demonstrated, there are no scientific standards or criteria for publishing a press release. So, while it may be accurate to report that a company is claiming that its products have “positive results,” that claim should be understood as biased from the outset.

Second, while failing to provide specifics (beyond the company’s own claims) about the alleged “positive results” of Mindset’s compounds, the story includes a number of self-promotional assertions, such as, “Mindset aims to develop next-generation psychedelic compounds that are pharmacologically optimized to treat neuropsychiatric conditions such as depression, anxiety, addiction, and post-traumatic stress disorder.” 

But how exactly does a company whose team consists largely of former mining, financial, and gaming executives plan on “pharmacologically optimizing” psychedelics to treat a myriad of diverse “neuropsychiatric conditions?” The story fails to offer even the faintest glimmer of insight. Considering that the mechanisms for treating the listed illnesses are varied and currently under research, such vague claims must be treated with skepticism by journalists who report on them. 

Oftentimes, corporations use press releases to attract investors and increase shareholder value. When media organizations disseminate the contents of these statements as though they are meaningful—without vetting or verifying the claims—they are essentially functioning as corporate megaphones, while presenting themselves as independent and impartial actors. 

Third, Lucid’s coverage claims, “It has been thought by some that psilocybin mushrooms contain metabolites that produce cardiotoxic effects,” citing a single questionable paper in the journal Acta Toxicologica, which labels naturally-occurring hallucinogens “addict agents” and the consumption of psilocybin-containing mushrooms as a “form of addiction.” The Acta Toxicologica paper discusses supposed cardiotoxicity among rats who received 10 μg/kg injections of psilocin every second day for 12 weeks. Setting aside questions about the efficacy of microdosing or the likelihood of humans adopting such dosing regimens, the fact is that many animal studies don’t translate to humans very well.

There is an overwhelming amount of evidence that psilocybin is one of the safest drugs on the planet. So why is psilocybin-induced cardiotoxicity being discussed as if it’s a problem to be solved through the creation of novel (proprietary) “psilocybin-inspired” compounds with unknown safety profiles? Perhaps this is a case of a (proprietary) “solution” in need of a problem.

Lucid’s discussion of psilocybin-induced cardiotoxicity opens with Mindset’s Vice President of Corporate Development, Jason Atkinson, claiming that Mindset’s compounds “have been pharmacologically optimized to help address some of the known shortfalls of psilocybin.” Subsequent (non-rat-related) claims about cardiotoxicity are attributed solely to Mindset (“Mindset is addressing its potential cardiotoxicity…”) and Atkinson (“Mindset’s goal with our novel compounds is…minimizing any negative side effects like cardiotoxicity”). 

This whole framing seems rather premature, as the press release mentions only successful “functional assays,” with future in vivo tests (tests on whole, living organisms) planned. The press release makes no mention of clinical trials whatsoever.  

When it comes to functional assays, the Encyclopedia of Psychopharmacology offers the following explanation:

“Stated simply, a drug binds to a receptor and then ‘does something.’ It is the purpose of functional assays to measure and quantitate that ‘something,’ with the choice and design of assay being highly dependent upon the type of receptor (i.e., GPCR or ion channel), as well as the effect being studied (agonism, antagonism, inverse agonism, or allosteric modulation).”

However, there are gaps in understanding which cellular changes correlate with desired therapeutic effects. As such, a functional assay may not measure the proper mechanism, as demonstrated by a recent study of psychedelic anti-inflammatories. 

Additionally, Lucid’s story does not acknowledge that the only source it cites for its claims of psilocybin-induced cardiotoxicity is a questionable study where investigators injected rats 42 times with 10 micrograms per kilogram of psilocin (the active metabolite of psilocybin) over a 12-week period. There are no additional citations or references attributed to Mindset or Atkinson for their mentions of cardiotoxicity. In fact, the broader scientific literature does not contain any peer-reviewed, controlled human studies on psilocybin-induced cardiotoxicity from microdosing psilocybin (or otherwise). 

The hypothetical “solutions” offered by Mindset’s experimental compounds with unknown safety profiles raise more questions than they answer. There is a well-established human-safety profile for psilocybin, and a clear lack of evidence regarding psilocybin-induced cardiotoxicity. But, Mindset is creating and testing “novel compounds” to minimize “any negative side effects like cardiotoxicity.” Why? Wouldn’t it make more sense to investigate the supposed cardiotoxicity (or other suggested “negative side effects”) of psilocybin before playing corporate Shulginite with proprietary alphabetamines of unknown safety? Perhaps not, if the goal is to create proprietary compounds for shareholder-enrichment, rather than addressing an unmet pharmacological need.

It appears that Lucid News is repeating unverified claims, advancing questionable and disingenuous information regarding the safety of psilocybin, and ultimately amplifying a message of questionable accuracy that serves a profit-motivated corporation, rather than the larger field of psychedelic science. While this brand of reporting doesn’t appear to be sponsored content, as commonly understood, the end result is remarkably similar: a seemingly authentic “news story” is framed as offering “objective reporting,” but instead it functions to disseminate camouflaged corporate public relations statements rather than offering insight into published, peer-reviewed science. 

This is what mainstreaming looks like as non-cooperative actors try to cash in on the “mush rush.” Skyrocketing numbers of press releases from psychedelic pharmaceutical start-ups, unfounded claims about the superiority of proprietary “psychedelic-inspired medicines,” and a variety of other questionable practices aimed at increasing shareholder value. This is the present reality, but psychedelic media outlets who participate in these dynamics are choosing to do so. They can (and should) make the choice to stop.

Let’s Talk About Adversarial and “Objective” Journalism

While some in the media may claim “objectivity” in pursuit of credibility and in defense of regurgitating corporate statements with little-to-no vetting, the above case study highlights the importance of adversarial journalism. Journalist and editor Frank Hartzell defines an adversarial approach as, “When a reporter, a newspaper or on rare occasions, a blog, stands up on behalf of the public to those in power. Spin and public relations are rejected…and reporters challenge every story based on its merits.” 

Adversarial approaches can help safeguard against “false balance,” a media bias in which “both sides” of an issue are treated as equally valid, irrespective of the evidence. Such approaches can also highlight important areas of inquiry when there’s only one “side” at hand, as is the case with corporate press releases. In the case of Lucid News and Mindset, wouldn’t it have been more “objective” to cross-reference corporate claims, rather than just “objectively” reporting what the company said as though it’s true? 

Claims of neutral “objectivity” obscure the fundamentally subjective nature of the human beings involved in any endeavor, whether journalistic or otherwise. Furthermore, “objective” reporting (for example, airing the president’s lies or presenting climate change as a “debate”), frequently fails to effectively interrogate the veracity of the claims covered by such reporting, and has contributed significantly to constructing and maintaining an increasingly post-truth world. 

A relatively fresh psychedelic pundit, who tends to run PR statements with more frequency and less scrutiny than seems prudent, nonetheless offered an insightful observation back in June, noting, “The actual value of a company is inversely related to the frequency of press releases.” Those in the media who struggle to acknowledge the myth of objectivity would do well to consider the implications of their approaches. Are they really advancing psychedelic science, discourse, and understandings? Or are they playing into the hands of pharmaceutical corporations, whether wittingly or unwittingly?

As longtime journalist and former lecturer at Sheffield University, Jonathan Foster, noted with regards to the responsibility of the press, “If someone says it’s raining, and another person says it’s dry, it’s not your job to quote them both. Your job is to look out the fucking window and find out which is true.” 


David Nickles

David Nickles is an underground researcher and harm reduction advocate. He has presented social critiques and commentary on psychedelic culture and radical politics, as well as novel phytochemical data from the DMT-Nexus, at venues around the world. David’s work focuses on the social and cultural implications of psychoactive substances, utilizing critical theory and structural analysis to examine the intersections of drugs and society. He is a vocal opponent of the mainstreaming and commodification of psychedelic compounds and rituals, believing that such approaches inherently obscure the liberatory potential of psychedelic experiences.

The post Psychedelic Media Should Stop Parroting Corporate Press Releases appeared first on Psymposia.

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We Need to Talk About MAPS Supporting The Police, The Military, and Violent White Supremacism https://www.psymposia.com/magazine/acab/ Fri, 17 Jul 2020 21:38:49 +0000 http://www.psymposia.com/?p=83644 For decades, MAPS and other proponents of psychedelic medicalization have justified their emphasis on treating police and soldiers as a political strategy in service to mainstreaming psychedelic drugs. This strategy perpetuates the logic of white supremacism, capitalism, and imperialism.

The post We Need to Talk About MAPS Supporting The Police, The Military, and Violent White Supremacism appeared first on Psymposia.

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Since estabishing The Multidisciplinary Association for Psychedelic Studies (MAPS) in 1986, founder and executive director, Rick Doblin, has consistently articulated his goal to medicalize psychedelic compounds in the hopes of securing mainstream acceptance of psychedelic drugs, users, and cultures. Numerous people, including myself, have critiqued this approach as relying on the framework of dominant culture (and the longstanding ills of capitalism, white supremacism, patriarchy, and industrial civilization), thereby reproducing the destructive logic of these systems. 

Doblin has consistently downplayed and dismissed these critiques. Additionally, under Doblin’s decades-long leadership, MAPS has failed to engage with assertions that its approach is little more than “respectability politics” meant to demonstrate that values within the “psychedelic community” are not at odds, but are in fact continuous with those of dominant culture. This approach endangers those of us who are commonly marginalized, brutalized, and murdered within dominant culture—and alienates us within psychedelic spaces that we may have sought out in pursuit of alternative cultural havens.

Over its 34 years of existence, MAPS has failed to provide meaningful historical evidence or coherent theoretical arguments for its strategy, relying instead on faith-based appeals to the “power” of psychedelics to “heal” society. In pursuit of medicalization and mainstreaming, Doblin has repeatedly argued that MAPS’ reputation and the legitimization of its research are more important than concerns about the sociopolitical implications of its research. For example, consider Doblin’s ongoing insistence on the importance of providing MDMA therapy to police and soldiers. Or notably, his defense of John Halpern, a former MAPS research collaborator at Harvard Medical School and DEA informant against William Leonard Pickard and Clyde Apperson. 

Irrespective of its justifications, MAPS has repeatedly courted the forces of authoritarianism and white supremacism as a political strategy in pursuit of mainstreaming psychedelics. This is true regardless of the personally held beliefs of MAPS employees; some of whom I’ve seen challenge Doblin, only to find themselves shouted down in front of other staff.

More recently, under the guise of generating “bipartisan support” (read: courting reactionaries) for MDMA-assisted psychotherapy for veterans, MAPS has promoted the positive coverage it received from the far-right site Breitbart, and has attempted to influence (mostly) far-right Republicans through its self-identified “conservative whisperer,” Veterans & Governmental Affairs Liaison, Jonathan Lubecky. It’s worth noting that Lubecky is absent from MAPS’ staff page.

Lubecky, a retired US Army sergeant who participated in a MAPS-sponsored MDMA trial, can be seen on his personal social media accounts posing with politicians and operatives across the political spectrum, including Donald Trump, Mike Pence, Steve Bannon, Rudy Giuliani, Joe Biden, Alex Jones, Matt Gaetz (R-FL), Cory Booker (D-NJ), Rand Paul (R-KY), Chuck Grassley (R-IA), and former Wisconsin governor Scott Walker.

Lubecky’s forays into reactionary territory aren’t the only evidence of MAPS’ myopic focus on its own political agenda. Similarly telling is the organization’s willingness to accept funding from all-things-conservative financier Rebekah Mercer and ATAI Life Sciences’ founder Christian Angermayer, and its unwillingness to speak out against Peter Thiel, the chairman of Palantir and recent investor in defense-contractor startup Anduril

Thiel has quickly become one of the largest investors in the emerging psychedelics industry. Thiel Capital Managing Director & Chief Medical Officer, Jason Camm, recently joined the board of ATAI Life Sciences. ATAI is the largest minority shareholder of COMPASS Pathways, founded by husband and wife team George Goldsmith and Katya Malievskaia. According to public documents, Goldsmith and Malievskaia have donated at least $455,000 to MAPS since 2013, including a recent donation of $300,000. Angermayer has donated at least $250,000 and Mercer has pledged $1,000,000. 

When directly questioned on the subject, Doblin has demonstrated an unwillingness to acknowledge the war on Black, Brown, and poor people facilitated by psychedelic funders and investors like Mercer and Thiel. In one interview, Doblin said, “I’ve seen articles claiming ‘Peter Thiel controls the flow of psilocybin’…‘He’s this evil guy doing all these things with Trump!’ It’s guilt by association, which is not fair” (hyperlink added). While it doesn’t appear that anyone aside from Doblin has suggested that “Thiel controls the flow of psilocybin,” there is undeniable evidence that “Thiel does Trump’s dirty work.

In light of these facts, it seems particularly absurd that on June 3, 2020, as a result of the national uprisings in response to the murder of George Floyd, Breonna Taylor, and countless others at the hands of police, MAPS published a press release entitled, “Statement of Solidarity: MAPS Stands Against Systemic Racism and for Justice and Healing.” The statement concludes by stating that, “MAPS and MAPS PBC [Public Benefit Corporation] are working every day to integrate a deeper anti-racist practice into our work. We have made slow, deliberate progress, and acknowledge that we have a long way to go. We commit to doing the work for collective liberation.” But MAPS’ work doesn’t evidence anti-racist principles; its main political strategy is based on demonstrating affinity for and utility to institutions and individuals who have repeatedly upheld violent white supremacism.

As long as its strategy relies on supporting the police and the military (institutions that exist to perpetuate white supremacism, class warfare, and imperialism) it’s not tenable for MAPS and its PBC to claim that they’re invested in “working every day to integrate a deeper anti-racist practice into [their] work.” Nor is it reasonable for them to assert that they’re committed to “doing the work for collective liberation,” as long as they’re accepting money from fascist oligarchs.

Below are some of the stances Doblin has taken over the years, indicating the degree to which MAPS has worked to support the institution of policing. In the following examples, it’s worth noting his focus on healing police, rather than the broader populace and victims of policing:

  • In 2006, Doblin said, “I starting [sic] thinking about how traumatic it would be for a police officer to see the murdered body of a pregnant woman. I experienced some compassion for the police.” As a result, “MAPS and Morley proceeded to develop a Memorandum of Understanding for a potential study of MDMA-assisted psychotherapy for PTSD in Canadian RCMP officers.”
  • In 2013, Alternet reported, “Doblin says MAPS would like to enroll the first police officer who has PTSD caused by work, in order to solidify the point that MDMA therapy can potentially benefit anyone.”
  • In 2015, Doblin wrote, “Thirty years ago, it was law enforcement—police and the DEA—who led the charge to criminalize MDMA. Thirty years later, we have actually enrolled and treated a police officer with service-related PTSD in our South Carolina Phase 2 studies, as well as three firefighters (including one who was at the World Trade Center on 9/11) and 20 U.S. military veterans.”
  • In 2016, Doblin said, “So, we’ve in our study we just finished with veterans, for political reasons what I wanted to do was to say, It’s for veterans, firefighters and police officers…I didn’t think we’d ever get any firefighters or police officers, but we did…Building those bridges to the police is just incredible.”
  • In 2018, Doblin gave a talk at the International Association of Chiefs of Police (IACP) Police Physicians Section Conference titled, “Recovering Cops from Severe PTSD: FDA Approved Psychedelic Treatment and Therapy.”
  • In 2019, while discussing his “treatment” of a retired cop at Burning Man, Doblin said, “And the fact that it was both a veteran and a retired police officer, the same person…it just made me think that this is the ideal kind of person we’re trying to show. If we’re trying to mainstream psychedelics, you know, what’s more mainstream than a veteran and a police officer?”

These examples evidence 14 years of MAPS and Doblin advocating MDMA-assisted therapies for the state-sanctioned white supremacist enforcers of capitalism who murder Black, Brown, Indigenous, and poor people with impunity. It’s worth noting that the police whom MAPS has been so eager to treat are the shock troops on the front lines of the war on [some people who use certain] drugs. This “war” has wrought the harms of incarceration, legal battles, surveillance, and death on members of communities MAPS claims to support, a point Doblin appears to chronically ignore or downplay in his rush to celebrate psychedelic treatments for law enforcement.

MAPS’ attempts to diversify psychedelic research have historically fallen short. A study intended to advance racially-diverse MDMA research at the University of Connecticut, headed by Dr. Monnica Williams, was terminated for a variety of reasons in 2018. A 2018 literature review—authored in-part by Dr. Williams—concluded, “The White washing of psychedelic drug use has unfortunately spread to medical research, as we find extremely low rates of participation by people of color in psychedelic-assisted psychotherapy studies and a lack of generalizability of these studies to critical clinical issues for people of color.” Perhaps Doblin’s public fawning over police offers some additional insight as to why his organization has struggled to productively engage with issues of race and class for decades. 

It should be noted that Doblin is fully aware of the critiques of his approach. Doblin and his staff have attended a number of talks I’ve presented that have critically analyzed their fixation on police and soldiers, and I have had multiple conversations with them on the topic. The reality is that they made the political choice of siding with police and soldiers, rather than the communities these forces occupy and brutalize on a daily basis. If MAPS truly wants to “integrate anti-racist practices” in order to “work for collective liberation,” it seems necessary for it to acknowledge and disavow the strategy it’s taken to-date.

It is incongruous for MAPS to publish a public relations statement in which it “commit[s] to doing the work for collective liberation” when Doblin has explicitly identified police as the “ideal kind of person” and called them “more mainstream” than the people they surveil, assault, and murder. Perhaps what MAPS actually means by “collective liberation” is “psychedelic research and therapy.” This would seem to present an updated “dose the water” theory of change, where therapists’ offices substitute for municipal water supplies. To date, no one has articulated a coherent explanation of how this would achieve “collective liberation.” However, this interpretation would explain at least some of the rationale for Doblin’s sheltering of John Halpern; a decision which provides additional evidence of MAPS’ affinity for police and their collaborators, rather than the communities they terrorize. 

For those unfamiliar with the tale of Halpern, I would recommend reading Jon Hanna’s Halperngate, Erik Davis’ The Bad Shaman Meets the Wayward Doc, and checking out the related Erowid vault. In brief, Halpern was an informant in the case of United States of America vs. William Leonard Pickard and Clyde Apperson, ultimately leading to Apperson receiving a thirty-year prison term and Pickard getting two life sentences for manufacturing and distributing LSD. In the context of examining MAPS’ prioritization of its research over “collective liberation,” perhaps the most relevant comment Doblin made in defense of Halpern is:

“After John’s cooperation with DEA began, I saw that he was motivated even more than before to work to end the suppression of scientific research with psychedelics, despite such research potentially being met with disapproval by DEA. John is a highly trained physician/researcher with a healthy measure of courage. I saw that he was committed to proceeding with integrity and an unwavering allegiance to the scientific method…Also, John was uniquely positioned at Harvard to make progress that nobody else was willing to even attempt…In retrospect, I continue to believe this decision to work together was correct, as evidenced by John’s expanding research.”

Doblin has repeatedly placed the sanctity of MAPS’ psychedelic research agenda above all else.

Even if we completely ignore MAPS’ long-standing eagerness to aid and abet cops and snitches, there’s still overwhelming evidence as to its support of white supremacist systems of domination at home and abroad. For years, Doblin has proudly discussed assisting the US military and the veterans of its numerous imperial conquests. Additionally, he and his organization have repeatedly courted objectionable donors, whose contributions they display as political trophies, completely ignoring (and at times incoherently ridiculing) the objections of those who point to the body counts and systemic violence of psychedelic funders such as Peter Thiel, Rebekah Mercer, and Christian Angermayer.

A since-deleted comment from Rick Doblin, using the MAPS Facebook account.

MAPS has sung the praises of military veterans so frequently that its focus on healing the perpetrators of large-scale international violence (rather than their millions of victims) should be common knowledge. What may come as a surprise is the fact that, in 2013, the organization actually tried “to persuade military medical officials to permit a clinical trial that would test MDMA…in active duty soldiers.” In 2013, US forces were deployed in 134 countries around the globe, maintaining US hegemony and the death, destruction, and exploitation such dominance requires. No reframing of history can spin aiding and abetting the US military, with its litany of war crimes, as “doing the work for collective liberation.” Yet the recent press release from MAPS suggests that readers should overlook these realities and instead buy into a mythical narrative of how the organization sees itself and the world.

The fixation on soldiers within the project of psychedelic medicalization largely hinges on the narratives associated with treating individuals mythologized as the protectors of American freedom and liberty. This strategy, in turn, creates opportunities to make inroads with conservatives, resulting in certain political and financial dividends. While Doblin has made a show of publicly questioning the likelihood that soldiers who have experienced psychedelic-assisted therapies will continue to wage war, he has also stated that he doesn’t actually believe MDMA will lead to soldiers leaving the military. Additionally, he has suggested that MDMA might make “better soldiers” and acknowledged secret military research into the use of MDMA. Doblin’s self-contradictions on the topic of treating soldiers highlight the bad math of his political calculations to “support the troops” in hopes of securing backing from the reactionary right. These calculations present direct threats to millions abroad as well as those of us who face the boomerang effects of US imperialism coming home to roost.

MAPS’ approach ignores the economic incentives for cost-saving psychedelic “maintenance therapies” in militarized contexts and the structural nature of military enlistment in the US. It’s expensive to train soldiers, especially those in high-skilled/high-stress positions like drone operators. If MDMA can be used to alleviate PTSD in active-duty soldiers, it not only prevents the military from hemorrhaging money on training while increasing combat readiness, it also offers convenient public relations narratives. The military can claim to have a cure on hand for its soldiers’ traumas, even as they cause untold trauma and death abroad—a line of thinking MAPS already seems quite comfortable with, based on its own statements and actions.

While pursuing approaches that bolster US imperialist narratives, MAPS has failed to present a coherent picture of how MDMA therapy for veterans (or active duty troops) inhibits the systemic drivers of military enlistment (likely because it doesn’t). In the US, “service members typically earn more than civilians with a comparable level of education. Moreover, they receive many other benefits that civilians often do not, including housing allowances, subsidized child care, tuition assistance, and top-of-the-line comprehensive health care.” Doblin has eagerly sought out collaboration with and funding from people who advocate the shredding of social safety nets, inevitably worsening those systemic drivers by attacking government funding for policies that could subsidize healthcare, food, shelter, and education. And psychedelic financiers like Thiel, Mercer, and Angermayer aren’t just invested in advancing dynamics that increase societal inequality and militarism, they’re actively engaged in bolstering policing and other projects of white supremacism and plutocratic class war.

As Psymposia previously stated in Dear Psychedelic Researchers, “Thiel’s list of antisocial and racist behaviors is too long to detail here (1, 2, 3, 4, 5, 6, 7, 8, 9…), [but] using surveillance technology to round up and deport Brown people, and supporting apartheid should cause alarm.” The fact of the matter is that Thiel’s endeavors have repeatedly reinforced the white supremacist status quo. Thiel’s technology has been deployed against drug users, and it’s hard to miss the connections between Doblin’s disregard for communal safety in defense of Halpern and his lack of concern about Thiel’s professional anti-drug endeavors.

I have personally raised objections about Thiel’s, Mercer’s, and Angermayer’s creation, funding, and support of repressive projects to Doblin and his staff—none of whom have engaged with my concerns in a serious manner. When Psymposia questioned Doblin about Thiel in 2018, Doblin replied, “What I wish were different were not that Peter Thiel have not invested in COMPASS, but I wish he would have donated to MAPS…Republicans need [psychedelics] more than anyone else.” Doblin’s unwillingness to engage seriously with these issues is disturbing.

All of this is to say that I don’t know what MAPS means when it states, “We commit to doing the work for collective liberation,” because the organization’s strategy, to date, has relied on the logic of what bell hooks calls “imperialist white supremacist capitalist patriarchy” and all of the authoritarian and reactionary components therein. Nor do I know what the organization means when it claims that “MAPS and MAPS PBC stand in solidarity with people collectively raising their voices to assert that Black lives matter,” because its decades-long canonization of the police and military—institutions charged with upholding American capitalism—is clearly and undeniably at odds with that assertion.

MAPS wraps itself in the flag of counterculture while simultaneously disavowing it.

No one would take a similar statement about “collective liberation” seriously if it came from any other pharmaceutical company. Some will protest that MAPS is different, because of its focus on PTSD and its attempts to mainstream psychedelics. Nevertheless, such critics must reconcile the simple reality that organizations cannot meaningfully fight trauma while providing material aid to those causing trauma on a global scale.

In reality, MAPS is not a liberatory organization; its psychedelic-political strategy is fundamentally antagonistic to liberatory struggle. MAPS has consistently promoted the police—purveyors of professionalized authoritarian violence—as the “ideal” vehicle for its project of mainstreaming psychedelics. Since May 26, rebels in all 50 states and countries around the world have demonstrated what liberatory struggle can look like. MAPS would do well to acknowledge the reality that its current strategy is predicated on complicity with policing at home and abroad, and ask itself if it’s really prepared to cut ties with all individuals and institutions that reinforce policing and white supremacism. Because, if MAPS really wants to commit to anti-racist and liberatory struggles, it must divest from its current strategy and stop supporting white supremacism.

 

Some Resources:

Bail Funds/Legal Help by City (live document)

Abolition

Ally Politics

Harm Reduction for Folks In The Streets:

Policing

Correction: In a previous version of this story we reported that George Goldsmith and Katya Malievskaia have donated at least $475,000 to MAPS since 2013. According to public documents the correct amount is at least $455,000. The story has been updated accordingly.


David Nickles

David Nickles is an underground researcher and harm reduction advocate. He has presented social critiques and commentary on psychedelic culture and radical politics, as well as novel phytochemical data from the DMT-Nexus, at venues around the world. David’s work focuses on the social and cultural implications of psychoactive substances, utilizing critical theory and structural analysis to examine the intersections of drugs and society. He is a vocal opponent of the mainstreaming and commodification of psychedelic compounds and rituals, believing that such approaches inherently obscure the liberatory potential of psychedelic experiences.

Since estabishing The Multidisciplinary Association for Psychedelic Studies (MAPS) in 1986, founder and executive director, Rick Doblin, has consistently articulated his goal to medicalize psychedelic compounds in the hopes of securing mainstream acceptance of psychedelic drugs, users, and cultures. Numerous people, including myself, have critiqued this approach as relying on the framework of dominant culture (and the longstanding ills of capitalism, white supremacism, patriarchy, and industrial civilization), thereby reproducing the destructive logic of these systems. 

Doblin has consistently downplayed and dismissed these critiques. Additionally, under Doblin’s decades-long leadership, MAPS has failed to engage with assertions that its approach is little more than “respectability politics” meant to demonstrate that values within the “psychedelic community” are not at odds, but are in fact continuous with those of dominant culture. This approach endangers those of us who are commonly marginalized, brutalized, and murdered within dominant culture—and alienates us within psychedelic spaces that we may have sought out in pursuit of alternative cultural havens.

Over its 34 years of existence, MAPS has failed to provide meaningful historical evidence or coherent theoretical arguments for its strategy, relying instead on faith-based appeals to the “power” of psychedelics to “heal” society. In pursuit of medicalization and mainstreaming, Doblin has repeatedly argued that MAPS’ reputation and the legitimization of its research are more important than concerns about the sociopolitical implications of its research. For example, consider Doblin’s ongoing insistence on the importance of providing MDMA therapy to police and soldiers. Or notably, his defense of John Halpern, a former MAPS research collaborator at Harvard Medical School and DEA informant against William Leonard Pickard and Clyde Apperson. 

Irrespective of its justifications, MAPS has repeatedly courted the forces of authoritarianism and white supremacism as a political strategy in pursuit of mainstreaming psychedelics. This is true regardless of the personally held beliefs of MAPS employees; some of whom I’ve seen challenge Doblin, only to find themselves shouted down in front of other staff.

More recently, under the guise of generating “bipartisan support” (read: courting reactionaries) for MDMA-assisted psychotherapy for veterans, MAPS has promoted the positive coverage it received from the far-right site Breitbart, and has attempted to influence (mostly) far-right Republicans through its self-identified “conservative whisperer,” Veterans & Governmental Affairs Liaison, Jonathan Lubecky. It’s worth noting that Lubecky is absent from MAPS’ staff page.

Lubecky, a retired US Army sergeant who participated in a MAPS-sponsored MDMA trial, can be seen on his personal social media accounts posing with politicians and operatives across the political spectrum, including Donald Trump, Mike Pence, Steve Bannon, Rudy Giuliani, Joe Biden, Alex Jones, Matt Gaetz (R-FL), Cory Booker (D-NJ), Rand Paul (R-KY), Chuck Grassley (R-IA), and former Wisconsin governor Scott Walker.

Lubecky’s forays into reactionary territory aren’t the only evidence of MAPS’ myopic focus on its own political agenda. Similarly telling is the organization’s willingness to accept funding from all-things-conservative financier Rebekah Mercer and ATAI Life Sciences’ founder Christian Angermayer, and its unwillingness to speak out against Peter Thiel, the chairman of Palantir and recent investor in defense-contractor startup Anduril

Thiel has quickly become one of the largest investors in the emerging psychedelics industry. Thiel Capital Managing Director & Chief Medical Officer, Jason Camm, recently joined the board of ATAI Life Sciences. ATAI is the largest minority shareholder of COMPASS Pathways, founded by husband and wife team George Goldsmith and Katya Malievskaia. According to public documents, Goldsmith and Malievskaia have donated at least $455,000 to MAPS since 2013, including a recent donation of $300,000. Angermayer has donated at least $250,000 and Mercer has pledged $1,000,000. 

When directly questioned on the subject, Doblin has demonstrated an unwillingness to acknowledge the war on Black, Brown, and poor people facilitated by psychedelic funders and investors like Mercer and Thiel. In one interview, Doblin said, “I’ve seen articles claiming ‘Peter Thiel controls the flow of psilocybin’…‘He’s this evil guy doing all these things with Trump!’ It’s guilt by association, which is not fair” (hyperlink added). While it doesn’t appear that anyone aside from Doblin has suggested that “Thiel controls the flow of psilocybin,” there is undeniable evidence that “Thiel does Trump’s dirty work.

In light of these facts, it seems particularly absurd that on June 3, 2020, as a result of the national uprisings in response to the murder of George Floyd, Breonna Taylor, and countless others at the hands of police, MAPS published a press release entitled, “Statement of Solidarity: MAPS Stands Against Systemic Racism and for Justice and Healing.” The statement concludes by stating that, “MAPS and MAPS PBC [Public Benefit Corporation] are working every day to integrate a deeper anti-racist practice into our work. We have made slow, deliberate progress, and acknowledge that we have a long way to go. We commit to doing the work for collective liberation.” But MAPS’ work doesn’t evidence anti-racist principles; its main political strategy is based on demonstrating affinity for and utility to institutions and individuals who have repeatedly upheld violent white supremacism.

As long as its strategy relies on supporting the police and the military (institutions that exist to perpetuate white supremacism, class warfare, and imperialism) it’s not tenable for MAPS and its PBC to claim that they’re invested in “working every day to integrate a deeper anti-racist practice into [their] work.” Nor is it reasonable for them to assert that they’re committed to “doing the work for collective liberation,” as long as they’re accepting money from fascist oligarchs.

Below are some of the stances Doblin has taken over the years, indicating the degree to which MAPS has worked to support the institution of policing. In the following examples, it’s worth noting his focus on healing police, rather than the broader populace and victims of policing:

  • In 2006, Doblin said, “I starting [sic] thinking about how traumatic it would be for a police officer to see the murdered body of a pregnant woman. I experienced some compassion for the police.” As a result, “MAPS and Morley proceeded to develop a Memorandum of Understanding for a potential study of MDMA-assisted psychotherapy for PTSD in Canadian RCMP officers.”
  • In 2013, Alternet reported, “Doblin says MAPS would like to enroll the first police officer who has PTSD caused by work, in order to solidify the point that MDMA therapy can potentially benefit anyone.”
  • In 2015, Doblin wrote, “Thirty years ago, it was law enforcement—police and the DEA—who led the charge to criminalize MDMA. Thirty years later, we have actually enrolled and treated a police officer with service-related PTSD in our South Carolina Phase 2 studies, as well as three firefighters (including one who was at the World Trade Center on 9/11) and 20 U.S. military veterans.”
  • In 2016, Doblin said, “So, we’ve in our study we just finished with veterans, for political reasons what I wanted to do was to say, It’s for veterans, firefighters and police officers…I didn’t think we’d ever get any firefighters or police officers, but we did…Building those bridges to the police is just incredible.”
  • In 2018, Doblin gave a talk at the International Association of Chiefs of Police (IACP) Police Physicians Section Conference titled, “Recovering Cops from Severe PTSD: FDA Approved Psychedelic Treatment and Therapy.”
  • In 2019, while discussing his “treatment” of a retired cop at Burning Man, Doblin said, “And the fact that it was both a veteran and a retired police officer, the same person…it just made me think that this is the ideal kind of person we’re trying to show. If we’re trying to mainstream psychedelics, you know, what’s more mainstream than a veteran and a police officer?”

These examples evidence 14 years of MAPS and Doblin advocating MDMA-assisted therapies for the state-sanctioned white supremacist enforcers of capitalism who murder Black, Brown, Indigenous, and poor people with impunity. It’s worth noting that the police whom MAPS has been so eager to treat are the shock troops on the front lines of the war on [some people who use certain] drugs. This “war” has wrought the harms of incarceration, legal battles, surveillance, and death on members of communities MAPS claims to support, a point Doblin appears to chronically ignore or downplay in his rush to celebrate psychedelic treatments for law enforcement.

MAPS’ attempts to diversify psychedelic research have historically fallen short. A study intended to advance racially-diverse MDMA research at the University of Connecticut, headed by Dr. Monnica Williams, was terminated for a variety of reasons in 2018. A 2018 literature review—authored in-part by Dr. Williams—concluded, “The White washing of psychedelic drug use has unfortunately spread to medical research, as we find extremely low rates of participation by people of color in psychedelic-assisted psychotherapy studies and a lack of generalizability of these studies to critical clinical issues for people of color.” Perhaps Doblin’s public fawning over police offers some additional insight as to why his organization has struggled to productively engage with issues of race and class for decades. 

It should be noted that Doblin is fully aware of the critiques of his approach. Doblin and his staff have attended a number of talks I’ve presented that have critically analyzed their fixation on police and soldiers, and I have had multiple conversations with them on the topic. The reality is that they made the political choice of siding with police and soldiers, rather than the communities these forces occupy and brutalize on a daily basis. If MAPS truly wants to “integrate anti-racist practices” in order to “work for collective liberation,” it seems necessary for it to acknowledge and disavow the strategy it’s taken to-date.

It is incongruous for MAPS to publish a public relations statement in which it “commit[s] to doing the work for collective liberation” when Doblin has explicitly identified police as the “ideal kind of person” and called them “more mainstream” than the people they surveil, assault, and murder. Perhaps what MAPS actually means by “collective liberation” is “psychedelic research and therapy.” This would seem to present an updated “dose the water” theory of change, where therapists’ offices substitute for municipal water supplies. To date, no one has articulated a coherent explanation of how this would achieve “collective liberation.” However, this interpretation would explain at least some of the rationale for Doblin’s sheltering of John Halpern; a decision which provides additional evidence of MAPS’ affinity for police and their collaborators, rather than the communities they terrorize. 

For those unfamiliar with the tale of Halpern, I would recommend reading Jon Hanna’s Halperngate, Erik Davis’ The Bad Shaman Meets the Wayward Doc, and checking out the related Erowid vault. In brief, Halpern was an informant in the case of United States of America vs. William Leonard Pickard and Clyde Apperson, ultimately leading to Apperson receiving a thirty-year prison term and Pickard getting two life sentences for manufacturing and distributing LSD. In the context of examining MAPS’ prioritization of its research over “collective liberation,” perhaps the most relevant comment Doblin made in defense of Halpern is:

“After John’s cooperation with DEA began, I saw that he was motivated even more than before to work to end the suppression of scientific research with psychedelics, despite such research potentially being met with disapproval by DEA. John is a highly trained physician/researcher with a healthy measure of courage. I saw that he was committed to proceeding with integrity and an unwavering allegiance to the scientific method…Also, John was uniquely positioned at Harvard to make progress that nobody else was willing to even attempt…In retrospect, I continue to believe this decision to work together was correct, as evidenced by John’s expanding research.”

Doblin has repeatedly placed the sanctity of MAPS’ psychedelic research agenda above all else.

Even if we completely ignore MAPS’ long-standing eagerness to aid and abet cops and snitches, there’s still overwhelming evidence as to its support of white supremacist systems of domination at home and abroad. For years, Doblin has proudly discussed assisting the US military and the veterans of its numerous imperial conquests. Additionally, he and his organization have repeatedly courted objectionable donors, whose contributions they display as political trophies, completely ignoring (and at times incoherently ridiculing) the objections of those who point to the body counts and systemic violence of psychedelic funders such as Peter Thiel, Rebekah Mercer, and Christian Angermayer.

A since-deleted comment from Rick Doblin, using the MAPS Facebook account.

MAPS has sung the praises of military veterans so frequently that its focus on healing the perpetrators of large-scale international violence (rather than their millions of victims) should be common knowledge. What may come as a surprise is the fact that, in 2013, the organization actually tried “to persuade military medical officials to permit a clinical trial that would test MDMA…in active duty soldiers.” In 2013, US forces were deployed in 134 countries around the globe, maintaining US hegemony and the death, destruction, and exploitation such dominance requires. No reframing of history can spin aiding and abetting the US military, with its litany of war crimes, as “doing the work for collective liberation.” Yet the recent press release from MAPS suggests that readers should overlook these realities and instead buy into a mythical narrative of how the organization sees itself and the world.

The fixation on soldiers within the project of psychedelic medicalization largely hinges on the narratives associated with treating individuals mythologized as the protectors of American freedom and liberty. This strategy, in turn, creates opportunities to make inroads with conservatives, resulting in certain political and financial dividends. While Doblin has made a show of publicly questioning the likelihood that soldiers who have experienced psychedelic-assisted therapies will continue to wage war, he has also stated that he doesn’t actually believe MDMA will lead to soldiers leaving the military. Additionally, he has suggested that MDMA might make “better soldiers” and acknowledged secret military research into the use of MDMA. Doblin’s self-contradictions on the topic of treating soldiers highlight the bad math of his political calculations to “support the troops” in hopes of securing backing from the reactionary right. These calculations present direct threats to millions abroad as well as those of us who face the boomerang effects of US imperialism coming home to roost.

MAPS’ approach ignores the economic incentives for cost-saving psychedelic “maintenance therapies” in militarized contexts and the structural nature of military enlistment in the US. It’s expensive to train soldiers, especially those in high-skilled/high-stress positions like drone operators. If MDMA can be used to alleviate PTSD in active-duty soldiers, it not only prevents the military from hemorrhaging money on training while increasing combat readiness, it also offers convenient public relations narratives. The military can claim to have a cure on hand for its soldiers’ traumas, even as they cause untold trauma and death abroad—a line of thinking MAPS already seems quite comfortable with, based on its own statements and actions.

While pursuing approaches that bolster US imperialist narratives, MAPS has failed to present a coherent picture of how MDMA therapy for veterans (or active duty troops) inhibits the systemic drivers of military enlistment (likely because it doesn’t). In the US, “service members typically earn more than civilians with a comparable level of education. Moreover, they receive many other benefits that civilians often do not, including housing allowances, subsidized child care, tuition assistance, and top-of-the-line comprehensive health care.” Doblin has eagerly sought out collaboration with and funding from people who advocate the shredding of social safety nets, inevitably worsening those systemic drivers by attacking government funding for policies that could subsidize healthcare, food, shelter, and education. And psychedelic financiers like Thiel, Mercer, and Angermayer aren’t just invested in advancing dynamics that increase societal inequality and militarism, they’re actively engaged in bolstering policing and other projects of white supremacism and plutocratic class war.

As Psymposia previously stated in Dear Psychedelic Researchers, “Thiel’s list of antisocial and racist behaviors is too long to detail here (1, 2, 3, 4, 5, 6, 7, 8, 9…), [but] using surveillance technology to round up and deport Brown people, and supporting apartheid should cause alarm.” The fact of the matter is that Thiel’s endeavors have repeatedly reinforced the white supremacist status quo. Thiel’s technology has been deployed against drug users, and it’s hard to miss the connections between Doblin’s disregard for communal safety in defense of Halpern and his lack of concern about Thiel’s professional anti-drug endeavors.

I have personally raised objections about Thiel’s, Mercer’s, and Angermayer’s creation, funding, and support of repressive projects to Doblin and his staff—none of whom have engaged with my concerns in a serious manner. When Psymposia questioned Doblin about Thiel in 2018, Doblin replied, “What I wish were different were not that Peter Thiel have not invested in COMPASS, but I wish he would have donated to MAPS…Republicans need [psychedelics] more than anyone else.” Doblin’s unwillingness to engage seriously with these issues is disturbing.

All of this is to say that I don’t know what MAPS means when it states, “We commit to doing the work for collective liberation,” because the organization’s strategy, to date, has relied on the logic of what bell hooks calls “imperialist white supremacist capitalist patriarchy” and all of the authoritarian and reactionary components therein. Nor do I know what the organization means when it claims that “MAPS and MAPS PBC stand in solidarity with people collectively raising their voices to assert that Black lives matter,” because its decades-long canonization of the police and military—institutions charged with upholding American capitalism—is clearly and undeniably at odds with that assertion.

MAPS wraps itself in the flag of counterculture while simultaneously disavowing it.

No one would take a similar statement about “collective liberation” seriously if it came from any other pharmaceutical company. Some will protest that MAPS is different, because of its focus on PTSD and its attempts to mainstream psychedelics. Nevertheless, such critics must reconcile the simple reality that organizations cannot meaningfully fight trauma while providing material aid to those causing trauma on a global scale.

In reality, MAPS is not a liberatory organization; its psychedelic-political strategy is fundamentally antagonistic to liberatory struggle. MAPS has consistently promoted the police—purveyors of professionalized authoritarian violence—as the “ideal” vehicle for its project of mainstreaming psychedelics. Since May 26, rebels in all 50 states and countries around the world have demonstrated what liberatory struggle can look like. MAPS would do well to acknowledge the reality that its current strategy is predicated on complicity with policing at home and abroad, and ask itself if it’s really prepared to cut ties with all individuals and institutions that reinforce policing and white supremacism. Because, if MAPS really wants to commit to anti-racist and liberatory struggles, it must divest from its current strategy and stop supporting white supremacism.

 

Some Resources:

Bail Funds/Legal Help by City (live document)

Abolition

Ally Politics

Harm Reduction for Folks In The Streets:

Policing

Correction: In a previous version of this story we reported that George Goldsmith and Katya Malievskaia have donated at least $475,000 to MAPS since 2013. According to public documents the correct amount is at least $455,000. The story has been updated accordingly.


David Nickles

David Nickles is an underground researcher and harm reduction advocate. He has presented social critiques and commentary on psychedelic culture and radical politics, as well as novel phytochemical data from the DMT-Nexus, at venues around the world. David’s work focuses on the social and cultural implications of psychoactive substances, utilizing critical theory and structural analysis to examine the intersections of drugs and society. He is a vocal opponent of the mainstreaming and commodification of psychedelic compounds and rituals, believing that such approaches inherently obscure the liberatory potential of psychedelic experiences.

The post We Need to Talk About MAPS Supporting The Police, The Military, and Violent White Supremacism appeared first on Psymposia.

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Bicycle Day 2020 Was Truly Historic, But Not for the Reasons You Think https://www.psymposia.com/magazine/rahn-mindmed-corporadelic-bicycle-day-lsd-patent/ https://www.psymposia.com/magazine/rahn-mindmed-corporadelic-bicycle-day-lsd-patent/#comments Sat, 25 Apr 2020 19:18:16 +0000 http://www.psymposia.com/?p=83548 Jamon A. Rahn, CEO of psychedelic pharmaceutical startup MindMed, offered a glimpse of the future of psychedelic science, including proprietary data and hints of an “LSD neutralizer.”

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David Nickles

By David Nickles|April 25, 2020

Jamon A. Rahn, CEO of psychedelic pharmaceutical startup MindMed, offered a glimpse of the future of psychedelic science, including proprietary data and hints of an “LSD neutralizer.”

Psymposia is a 501(c)(3) nonprofit research and media organization that offers critical perspectives on drugs, politics, and culture. We rely on contributions from our readers and listeners. Your support is vital to sustaining Psymposia.

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Support Psymposia’s independent journalism on Patreon and help us drive the Mystery Machine! We’re a bunch of meddling kids who are unmasking the latest shenanigans on the psychedelics beat.

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If COMPASS Pathways’ incorporation on June 13, 2016 marked the beginning of the end for open science in psychedelic research, April 19, 2020 may very well have marked the end of the beginning for the Corporadelic Era. Numerous psychedelic celebrities spoke at virtual Bicycle Day events commemorating Albert Hofmann’s infamous bike ride. However, the most notable occurrence of the day may have been an offhand comment made by a corporate invitee at an event hosted by Jackee Stang, founder of Delic Corp (the organization that swallowed Reality Sandwich).

In an interview with Stang, Jamon “JR” Rahn, the co-founder of psychedelic pharmaceutical startup MindMed—who used to advise “a group of Asian investors to structure and manage commodity-streams and trading opportunities into foreign mining companies”—offered a glimpse into the proprietary future of psychedelic science. In light of MindMed’s recent acquisition of an exclusive license to the “data, compounds, and patent rights” associated with Dr. Matthias Liechti’s research into LSD and other psychedelic compounds at the University of Basel, Rahn was asked what he had learned from this newly acquired data. His response was telling.

With a big smile, Rahn stated, “We’ve learned a lot, actually. We are a public company, so I can’t necessarily talk about a lot of what we learned, but everyone should stay tuned because we definitely want to talk more about how we’re advancing LSD through this data and how we ultimately want to make medicines that are better for patients, but also helpful to therapists.”

This reply sits alongside COMPASS Pathways’ attempts to patent Albert Hofmann’s psilocybin synthesis in signalling that the aggressive tactics and proprietary approaches to intellectual property all-too-common in the world of Big Pharma are seeping into the fields of psychedelic science. Rahn’s comments stand in sharp contrast to the type of information and data sharing that have been commonplace within sanctioned (and underground) psychedelic research since Hofmann invented LSD and Sandoz made it readily available to researchers around the world.

On April 21, 2020, MindMed published a press release that could offer a glimpse of what Rahn may have been hinting at with his talk of helping therapists. This press release claimed that MindMed had developed “a neutralizer technology intended to shorten and stop the effects of an LSD trip during a therapy session.” While the press release didn’t identify the compound in question, one possible candidate could be ketanserin (a 5-HT2A antagonist), which Liechti’s lab previously described using in order to block effects from LSD. This has also been described elsewhere since at least 1998.

When reached for comment, Dr. Matthew Baggott, psychedelic researcher and former Director of Data Science and Engineering at Genentech, indicated that he thought using a 5-HT2A antagonist to stop a trip was obvious to a skilled practitioner and therefore not patentable. “We already know 5-HT2A antagonists prevent the effects of LSD or psilocybin if given in advance. And 5-HT2A antagonists can decrease hallucinatory syndromes in ongoing disease states.  So it stands to reason that 5-HT2A antagonists could stop a trip. In fact, it’s an obvious enough idea that websites selling grey market psychedelics have sold ketanserin for this purpose.”

Baggott went on to question the practical value of a medicine that stops psychedelic trips, “Terminating a trip because it becomes challenging or scary is often not in the best interest of the patient. Most therapists would recommend working with the experience, not trying to end it.” 

For Baggott, this raises a question of whether a patent on this idea would even be worth the expense of filing it, “I wonder if MindMed has really thought about who would buy this. Therapists won’t want it.  And, in the ER, where patients might be on multiple unknown drugs and have underlying mental health conditions, I imagine you’d treat apparent bad trips with a benzodiazepine, not something that is drug-class-specific. It makes me wonder, does this patent even have any value beyond generating publicity?”

In that same April 21 press release, MindMed appeared to attempt to insulate itself from critiques from within the “psychedelic community” by presenting some legal realities of patent law as though they were operating “principles” of its business model, stating:

“[MindMed] operates under the principle that long known psychedelic compounds themselves must remain in the public domain….”

But this isn’t unique to MindMed, this is how “prior art” and the “public domain” work. Prior art is any evidence that a given invention (in this case, a psychedelic compound) is already known. For example, COMPASS Pathways withdrew all 27 of its “claims of novelty” when experts demonstrated that its claims were covered by Albert Hofmann’s pre-existing psilocybin synthesis. In this quote, MindMed is simply stating it won’t take the same (failed) approach as COMPASS. This is little more than virtue signalling in an attempt to placate skeptics of for-profit, non-cooperative pharmaceutical approaches.

The press release also stated:

“MindMed defines [the bargain between innovators and the public] as a time-limited exclusive right for the patent owner to generate a return for funding the invention in exchange for dedicating the invention to the public domain once the patent term has expired.”

To be clear, this isn’t MindMed’s definition, this is actually how patent law is written in numerous federal and international contexts. The patent owner has exclusive rights to the patented invention until the patent expires, at which point the invention enters the public domain.

To the extent that these “principles” are actually enforced by governments, we can expect MindMed to adhere to them, but it would be foolish to mistake these proclamations as anything remotely approaching the spirit of open science. Rahn’s answer to Stang revealed his priorities: earning a return for his investors. To cap off an ugly couple of weeks for MindMed—including tasteless remarks about profiting off of the mental health effects of coronavirus—Rahn made it clear in Forbes where he and his company stand with regards to psychedelics more generally, stating, “I want nothing to do with those kinds of folks who want to decriminalize psychedelics.”

MindMed is presenting a familiar cluster of symptoms endemic to pharmaceutical companies within late stage capitalism: a lack of willingness to share data, aggressive patenting, and pretending that the high costs associated with treatment in this context are simply the “price of progress.” This destructive syndrome has proliferated ever since big pharma was captured by the one percent. Unfortunately—if history is any indicator—without immediate intervention, the diagnosis is likely terminal for true innovation and exploration within the fields of psychedelic science.


David Nickles

David Nickles is an underground researcher and harm reduction advocate. He has presented social critiques and commentary on psychedelic culture and radical politics, as well as novel phytochemical data from the DMT-Nexus, at venues around the world. David’s work focuses on the social and cultural implications of psychoactive substances, utilizing critical theory and structural analysis to examine the intersections of drugs and society. He is a vocal opponent of the mainstreaming and commodification of psychedelic compounds and rituals, believing that such approaches inherently obscure the liberatory potential of psychedelic experiences.

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Eleusis Benefit Corp: Taking the “Psychedelic” Out of Psychedelics https://www.psymposia.com/magazine/eleusis-benefit-corp-microwashing/ https://www.psymposia.com/magazine/eleusis-benefit-corp-microwashing/#comments Tue, 11 Feb 2020 06:26:38 +0000 http://www.psymposia.com/?p=83574 Shlomi Raz, CEO of Eleusis Benefit Corporation, made false claims about psychedelics. We asked multiple ethnobotanists, a medical anthropologist, and a chemist if they could help us set the record straight.

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David Nickles

By David Nickles|February 11, 2020

Shlomi Raz, CEO of Eleusis Benefit Corporation, made false claims about psychedelics. We asked multiple ethnobotanists, a medical anthropologist, and a chemist if they could help us set the record straight.

Psymposia is a 501(c)(3) nonprofit research and media organization that offers critical perspectives on drugs, politics, and culture. We rely on contributions from our readers and listeners. Your support is vital to sustaining Psymposia.

Support us on Patreon

Support Psymposia’s independent journalism on Patreon and help us drive the Mystery Machine! We’re a bunch of meddling kids who are unmasking the latest shenanigans on the psychedelics beat.

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As debates about the future of psychedelic legalization begin to appear in mainstream publications, the core message of would-be psychedelic profiteers is crystalizing into an all-too-Trumpian slogan, “Make psychedelics boring again.” The Defense Advanced Research Projects Agency (DARPA) is attempting to develop psychedelic analogues without “significant side effects” (e.g. “the trip”), while unethical entrepreneurs hype microdosing schemes through the BBC. Perhaps it’s unsurprising that corporate actors and military strategists are seeking to strip out the visionary (read: psychedelic) components of psychedelic experiences. After all, psychedelics have long been hailed as potential catalysts of revolutionary, countercultural change; hardly the ideal marketing narrative for consumer products intended to perpetuate industrial capitalism, or the status quo of US militarism.

The rebranding of psychedelics from “psychedelics”—literally, “mind-manifesting” visionary compounds, capable of catalyzing insight and resistance to dominant culture—into sub-perceptible “microdoses” marks a clear attempt at mainstream recuperation of these potent countercultural tools. As author and media theorist, Douglas Rushkoff, observed nearly 20 years ago, “Since the 1960s, mainstream media has searched out and co-opted the most authentic things it could find in youth culture, whether that was psychedelic culture, anti-war culture, blue jeans culture…they’ll look for it and then market it back to kids at the mall.” As proponents of psychedelic mainstreaming and medicalization disseminate revisionist histories to justify their approaches, we are observing the transformation of psychedelics into market commodities in real time.

Enter Shlomi Raz, CEO of Eleusis Holdings Limited (also known as Eleusis Benefit Corporation), a for-profit pharmaceutical company focused on, “Unlocking the anti-inflammatory potential of psychedelics.” In a recent opinion piece for STAT, Raz attempts to extend the “micro-washing” of psychedelics beyond the current fad of self-improvement supplementation and bring it into a fully-medicalized, pharmaceutical context. To this end, Raz concocts an all-encompassing, neocolonial narrative of “traditional” microdosing; a creation myth that sets the stage for Eleusis to pretend that it’s part of some long-standing psychedelic lineage of microdosing. In reality, Eleusis is just a pharmaceutical company looking to market a variety of low-dose psychedelic medicines, including LSD and 2,5-Dimethoxy-4-iodoamphetamine (DOI), a psychedelic phenethylamine first synthesized by Dr. Alexander Shulgin, and later Dr. David Nichols.

Raz briefly discusses scientific studies of higher-dose psilocybin, LSD, and ayahuasca experiences before casually stating that, “These high-profile research findings have obscured the primary traditional use of these medicines — as imperceptible anti-inflammatory agents.”  Raz makes no attempt to identify any specific cultures or substances here; implicitly lumping all “traditional” practices with all psychedelics into a monolithic notion of “primary traditional use.” He then takes this neocolonial homogenization one step further by asserting (without evidence) that this, “primary traditional use,” was, “as imperceptible anti-inflammatory agents.” 

Required reading for the ethnobotanically-inclined

Given the varied ritual and medical ethnobotanical applications across cultures that ingest similar psychedelic preparations—to say nothing of the widely-varied traditions between cultures that use different psychedelic preparations—Raz’s assertion of a singular “primary traditional use” of psychedelics fails even the most preliminary sniff test. One need only skim through ethnobotanical reference works, such as Garden of Eden, by Snu Voogelbreinder, The Encyclopedia of Psychoactive Plants, by Christian Rätsch, or Plants of the Gods, by Richard Evans Schultes and Albert Hofmann, to understand how nonsensical this claim is. 

That’s not to say that the research side of Eleusis is entirely without merit. The investigation of LSD for Alzheimer’s disease is certainly intriguing. Furthermore, exploring the potent psychedelic, DOI, for use as an anti-inflammatory agent is absolutely fascinating. In 2012, Dr. David Nichols shared the story of how his son, Dr. Charles Nichols (now employed as Eleusis’ lead scientist), discovered the surprising anti-inflammatory potential of DOI. The story of this discovery appears to present yet another case of psychedelic serendipity, and the science behind the treatment itself may be truly revolutionary. However, there’s an incredibly important distinction to make between finding anti-inflammatory applications for substituted phenethylamines and fabricating wholesale narratives about “the traditional use” of psychedelics.

When reached for comment as to Raz’s claims, Dr. David Nichols replied:

“I don’t believe that the ‘primary traditional use’ of psychedelics was as ‘imperceptible anti-inflammatory agents.’ Nevertheless, it is true that all the claims for antidepressant, anxiolytic, and anti-addictive properties for psychedelics have relegated the anti-inflammatory properties of psychedelics to the shadows; almost no one is aware that they are potent anti-inflammatories.”

To be clear, there are bodies of folk knowledge and peer-reviewed papers documenting anti-inflammatory applications of psychedelics. However, Raz didn’t merely lament a lack of public awareness regarding the anti-inflammatory potential of psychedelics; he asserted that “imperceptible anti-inflammatory” applications were the “primary traditional use” of psychedelics. In light of the readily available ethnobotanical information—or the fact that he could have simply consulted the father of his lead scientist—it’s hard to overstate the absurdity of Raz’s generalized, sweeping assertion.

 

“This subject merits some actual study rather than trying to somehow force fit it with microdosing.”

 

Even the paper that Raz cites in his STAT article, The Appeal of Peyote (Lophophora Williamsii) as a Medicine, doesn’t contend that peyote’s main application was as an “imperceptible anti-inflammatory agent.” Additionally, Raz misrepresents his source, claiming:  

“Eighty years ago, the renowned Harvard ethnobotanist Richard Evans Schultes wrote that the use of low-dose peyote was ‘centered around the therapeutic and stimulating properties of the plant and not around its vision-producing properties…Some of the ills listed as responding to peyote were tuberculosis, pneumonia, scarlet fever, intestinal ills, diabetes, rheumatic pains, colds, grippe, fevers, and venereal diseases…It is used as a white man uses aspirin.’” 

This quote is disingenuous on several levels and comprised of sentence fragments pulled from two separate sections of the paper in question. Most significantly, none of the sentences that Raz has spliced together offer comment on “low-dose peyote.” Furthermore, the list of ills is in the context of groups who, “rely on the cactus as a panacea,” and for whom, “there is hardly a disease which is not believed to be curable with peyote.”

That said, the paper does discuss observations of indigenous people eating, “one [button] between meals as a sort of appetizer,” and the fact that, “Several mescal buttons are given three times during childbirth among the Kiowa, Kickapoo, Shawnee, and probably other Plains tribes.” While the paper discusses “therapeutic,” “pseudo-therapeutic,” “medical,” “medico-religious,” and “superstitious” applications of peyote, at no point does it discuss “imperceptible anti-inflammatory” peyote regimens as “the primary traditional use.” In other words, the only work Raz actually cites for his claim simply doesn’t support it.

Psymposia reached out to a number of experts for comment on Raz’s article. We received replies from six ethnobotanists, all of whom expressed skepticism about Raz’s claim. Two of them declined to comment publicly. However the other four offered the following remarks.

Keeper Trout, noted cactus expert, ethnobotanist, and independent researcher, said:

“As for the long-time use of peyote as an analgesic and anti-inflammatory this was, and still is, something involving its topical application and is doubtful that it is related to the low level of mescaline. Ariocarpus fissuratus and A. kotschoubeyanus are both used similarly to peyote as a topical liniment for rheumatism, joint pain or pain resulting from blows or bruises. As far as I am aware, mescaline is the only psychedelic in the peyote plant and it does not occur in Ariocarpus species. This subject merits some actual study rather than trying to somehow force fit it with microdosing. Most medicinal applications of peyote involving ingestion for treating illnesses, such as Schultes mentioned, are at fully active dosage levels. It is also noteworthy Schultes was simply summarizing what he had come across and did not vouch for peyote’s efficacy in those applications.”

Snu Voogelbreinder, ethnobotanist and author of the aforementioned, Garden of Eden, one of the most comprehensive ethnobotanical reference books available, stated:

“That is indeed an odd thing for Raz to say…it appears he has applied some therapeutic uses of peyote as though all psychedelic plants have those common uses – and I’d say those uses for peyote are not as common as suggested, because it is not plentiful enough in the wild. Maybe a long time ago there was enough of it growing that people would use it for all those minor ailments and still be sustainable harvesters, but I think numerous other medicinal plants would be used for such minor complaints in most cases. Without doubt, peyote’s spiritual uses have far greater cultural importance, as would be the case for any other visionary plant. Any other medicinal properties are a bonus – there are plenty of non-visionary plants that have such therapeutic effects…”

Dr. Glenn Shepard, ethnobotanist, medical anthropologist, and Emmy-Award-winning documentarian, commented:

“It is indeed true that visionary plants often have myriad other cultural uses and physiological effects, sometimes confirmed in bioassays, that are incorporated into holistic concepts of healing in indigenous medical systems. The Western obsession with psychoactive experiences has often eclipsed our understandings of such nuanced and multifaceted uses of plant medicines. However to assert, in broad terms, that a specific property (in this case, low dose anti-inflammatory response) is the primary use of ‘psychedelic medicines’ is to take such a corrective gesture to the opposite extreme, once again doing disservice to complex and holistic indigenous notions of health, healing and medicine.”

Dr. Constantino Manuel Torres, ethnobotanist and archeologist known for his extensive research into the Taino use of Anadenanthera snuffs, replied: 

“To state that ‘the primary traditional use of [psychedelic] medicines — as imperceptible anti-inflammatory agents,’ is not correct. The statement is contradictory in itself: a primary use that is imperceptible(?).”

These replies offer significant evidence as to Raz’s lack of ethnobotanical credibility. But what about the other substances he discusses, such as LSD? Whether we situate “traditional” North American LSD use within the context of MK-ULTRA, The Diggers, The Merry Pranksters, The Grateful Dead Family, or any of the more discrete cultural movements associated with it, nowhere do we see a, “primary traditional use,” of LSD as an, “imperceptible anti-inflammatory agent,” quite the contrary.

“Hey Nick, how many microdoses are there in 2.8 kilos of ergotamine tartrate, again?”

Ken Kesey inquired, “Can you pass the acid test?” Jimi Hendrix asked, “Are you experienced?” Nick Sand heard a voice tell him, “Your job on this planet is to make psychedelics and turn on the world.” None of them were referring to “imperceptible anti-inflammatory” doses of LSD, not even close. Kesey—hardly alone in his assessment of LSD as being an incredibly powerful catalyst for personal and societal change—observed

“I believe that with the advent of acid, we discovered a new way to think, and it has to do with piecing together new thoughts in your mind. Why is it that people think it’s so evil? What is it about it that scares people so deeply, even the guy that invented it, what is it? Because they’re afraid that there’s more to reality than they have ever confronted. That there are doors that they’re afraid to go in, and they don’t want us to go in there either, because if we go in, we might learn something that they don’t know. And that makes us a little out of their control.”

 

“In this role Shlomi helped pioneer the use of derivatives, both as weapons of mass financial destruction, as well as for the betterment of mankind.”

 

In discussing Raz, it’s worth examining how he presents himself. His biography, as published alongside a (now-deleted flickr page for a) talk he gave at the President Street Forum, entitled, “Game Theory and Brain Washing – A Practitioner’s Guide,” read:

Rich Uncle Pennybags: Just another “soldier of fortune.”

 “…In 2003 he left JPMorgan and joined Goldman Sachs, rising to Managing Director responsible for Structured Product marketing. In this role Shlomi helped pioneer the use of derivatives, both as weapons of mass financial destruction, as well as for the betterment of mankind. In December 2008, Shlomi received notice that he was the target (amongst many others) of a Department of Justice investigation into Anti-Trust practices relating to work at JPMorgan…and like the A-Team, has gone underground, surviving as a soldier of fortune.” [hyperlink added for reference]

As such, we should understand Raz to be intimately acquainted with and fluent in the structures and systems of speculative capitalism. So, why has this self-professed mercenary taken such an interest in psychedelic pharmaceuticals? If we consider his bankster background, the current speculative investing in psychedelic medicines, and the fact that his company stands to benefit financially from his (false) narrative about “traditional use,” the answer seems clear: it’s a cash grab. Micro-washing the ethnobotanical record in order to create new markets for Eleusis’ products appears to be a ploy to enrich both Raz and his company.

Psymposia reached out to Raz multiple times for comment, but received no reply.

Regardless of industry, personal resumes matter: they offer insight into professional competence, ethics, and in many cases, philosophy. Just as with former Eleusis collaborator and COMPASS Pathways founder, George Goldsmith—whose past work at McKinsey & Co should raise eyebrows—Raz’s gloating about his role in creating, “weapons of mass financial destruction,” should give even a casual observer pause. It’s not that financial players have never been part of the modern psychedelic scene; quite the contrary. It’s that these capitalists—going back at least as far as JP Morgan executive and amateur mycologist, Gordon Wasson—have been demonstrably ruinous to psychedelic cultures, whether indigenous or industrial. Furthermore, in his STAT article, Raz has demonstrated a clear lack of credibility through his self-serving, mythical narrative. 

Snu Voogelbreinder elaborated:

“Some people may need a human therapist to assist with [visionary psychedelic experiences], others may not, but I believe it’s a mistake to see these compounds as drugs that must be made ‘safe’ to use by the standards of societies that fear them. Rather, societies need to adapt themselves to embrace and understand these substances and the states they induce, so that we can get the most out of them, healing not privileged individuals who can afford treatment, but anyone who needs them. Psychedelics can help us with so much more than mere depression and inflammation-related illness. Raz and company wish to make psychedelics ‘mainstream and boring again,’ as if they were ever that to begin with. Psychedelics might become mainstream, but never boring, even if some researchers choose to ignore their full import.”

As Shlomi Raz, Paul Austin, and even researchers such as Dr. Charles Nichols cry out to, “Make psychedelics boring again,” we must recognize that these reactionary impulses stem from a self-interested, capitalist logic of personal profit. Commodification requires such mass-marketing ploys to depoliticize substances long-hailed for inciting recognition of our fundamental interconnectedness.

Yaaaaaaaaaaaay, boredom!

The greatest good psychedelics can offer may reside in catalyzing visionary insight into alternative sociopolitical systems and inspiring collective action, not enriching shareholders through peddling pharmaceuticals aimed at treating the symptomatic fallout of our increasingly toxic environments. This potential requires coherent historical and sociopolitical analyses through which to apply psychedelic insight, rather than simplified narratives aimed at mainstreaming.

Micro-washing psychedelics to render them palatable, profitable, and impotent for anything beyond individually-focused therapies obscures an invaluable lens for confronting the realities of skyrocketing socioeconomic inequality, government-sanctioned ecocide, and a doomsday clock creeping ever-closer to midnight

Despite a few dealers, psychedelics have never been about profiteering. Despite their long-standing integration into some cultures, psychedelics have never been boring.

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Perhaps instead of Humphrey Osmond’s, “To fathom Hell or soar angelic, just take a pinch of psychedelic,” Shlomi Raz would propose, To keep humanity asleep and snoring, make psychedelics plain and boring.


David Nickles

David Nickles is an underground researcher and harm reduction advocate. He has presented social critiques and commentary on psychedelic culture and radical politics, as well as novel phytochemical data from the DMT-Nexus, at venues around the world. David’s work focuses on the social and cultural implications of psychoactive substances, utilizing critical theory and structural analysis to examine the intersections of drugs and society. He is a vocal opponent of the mainstreaming and commodification of psychedelic compounds and rituals, believing that such approaches inherently obscure the liberatory potential of psychedelic experiences.

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